Flotillins in the intercalated disc are potential modulators of cardiac excitability.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2018.11.007
Abstract: BACKGROUND The intercalated disc (ID) is important for cardiac remodeling and has become a subject of intensive research efforts. However, as yet the composition of the ID has still not been conclusively resolved and the… read more here.
Keywords: flotillin flotillin; flotillin; flotillins intercalated; intercalated disc ... See more keywords
Flotillin-mediated endocytosis and ALIX–syntenin-1–mediated exocytosis protect the cell membrane from damage caused by necroptosis
Sign Up to like & getrecommendations! Published in 2019 at "Science Signaling"
DOI: 10.1126/scisignal.aaw3423
Abstract: Two independent trafficking pathways remove phosphorylated MLKL from the plasma membrane to avert necroptosis. Exit the necroptosis executioner In cells dying by necroptosis, the pseudokinase MLKL becomes phosphorylated and competent to rupture the plasma membrane.… read more here.
Keywords: flotillin; necroptosis; phosphorylated mlkl; membrane ... See more keywords
Flotillin-2 predicts poor prognosis and promotes tumor invasion in intrahepatic cholangiocarcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Oncology Letters"
DOI: 10.3892/ol.2020.11349
Abstract: Intrahepatic cholangiocarcinoma (iCCA) is a highly malignant neoplasm arising from the intrahepatic bile ducts. As a scaffold protein of lipid rafts, flotillin-2 is upregulated in several types of cancer and promotes tumor progression and metastasis.… read more here.
Keywords: flotillin; poor prognosis; invasion; intrahepatic cholangiocarcinoma ... See more keywords