Enabling Technologies in Carbohydrate Chemistry: Automated Glycan Assembly, Flow Chemistry and Data Science
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200607
Abstract: The synthesis of defined oligosaccharides is a complex task. Several enabling technologies have been introduced in the last two decades to facilitate synthetic access to these valuable biomolecules. In this concept, we describe the technological… read more here.
Keywords: automated glycan; assembly flow; chemistry; glycan assembly ... See more keywords
Amide Bonds Meet Flow Chemistry: A Journey into Methodologies and Sustainable Evolution.
Sign Up to like & getrecommendations! Published in 2022 at "ChemSusChem"
DOI: 10.1002/cssc.202200301
Abstract: Invited for this month's cover are Antonella Ilenia Alfano and Margherita Brindisi (University of Naples Federico II) and Heiko Lange (University of Milano Bicocca). The cover image highlights the impact of greener and more sustainable… read more here.
Keywords: chemistry journey; meet flow; bonds meet; chemistry ... See more keywords
The creation and testing of a fully continuous tubular crystallization device suited for incorporation into flow chemistry setups
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Flow Chemistry"
DOI: 10.1007/s41981-019-00042-z
Abstract: The study presents the use of a continuous crystallization device that can be directly incorporated into flow chemistry setups. Inside this device spontaneous nucleation and growth of organic molecules are controlled and maintained, using Aspirin… read more here.
Keywords: flow chemistry; crystallization device; chemistry;
Extending practical flow chemistry into the undergraduate curriculum via the use of a portable low-cost 3D printed continuous flow system
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Flow Chemistry"
DOI: 10.1007/s41981-020-00122-5
Abstract: Continuous flow chemistry is undergoing rapid growth and adoption within the pharmaceutical industry due to its ability to rapidly translate chemical discoveries from medicinal chemistry laboratories into process laboratories. Its growing significance means that it… read more here.
Keywords: flow chemistry; system; chemistry; continuous flow ... See more keywords
Utilization of flow chemistry in catalysis: New avenues for the selective synthesis of Bis(indolyl)methanes
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron"
DOI: 10.1016/j.tet.2017.02.026
Abstract: Abstract Flow chemistry enables the preparation of bis(indolyl)methanes from various indoles and structurally divergent aldehydes using Sc(OTf) 3 catalysis. The reaction is regioselective for C-3 functionalization of the indoles, occurring over short reaction times allowing… read more here.
Keywords: indolyl methanes; flow chemistry; chemistry; bis indolyl ... See more keywords
Emerging Trends in Flow Chemistry and Applications to the Pharmaceutical Industry.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b01760
Abstract: The field of flow chemistry has garnered considerable attention over the past 2 decades. This Perspective highlights many recent advances in the field of flow chemistry and discusses applications to the pharmaceutical industry, from discovery… read more here.
Keywords: flow chemistry; pharmaceutical industry; chemistry; emerging trends ... See more keywords
Catalytically Active Inclusion Bodies─Benchmarking and Application in Flow Chemistry.
Sign Up to like & getrecommendations! Published in 2022 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.2c00035
Abstract: In industries, enzymes are often immobilized to obtain stable preparations that can be utilized in batch and flow processes. In contrast to traditional immobilization methods that rely on carrier binding, various immobilization strategies have been… read more here.
Keywords: chemistry; flow; inclusion bodies; flow chemistry ... See more keywords
Mimicking the surface and prebiotic chemistry of early Earth using flow chemistry
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-04147-2
Abstract: When considering life’s aetiology, the first questions that must be addressed are “how?” and “where?” were ostensibly complex molecules, considered necessary for life’s beginning, constructed from simpler, more abundant feedstock molecules on primitive Earth. Previously,… read more here.
Keywords: flow chemistry; mimicking surface; prebiotic chemistry; chemistry ... See more keywords
Organometallic flow chemistry: solvento complexes.
Sign Up to like & getrecommendations! Published in 2022 at "Dalton transactions"
DOI: 10.1039/d2dt02583c
Abstract: Photolysis under optimised flow conditions of metal carbonyls [{Ln}M(CO)x] [{Ln}M(CO)x = Cr(CO)6, Mo(CO)6, W(CO)6, Mn(CO)3(η-C5H4Me), Re(CO)3(η-C5H5)] in tetrahydrofuran (THF) conveniently affords the synthetically versatile and labile solvento complexes [{Ln}M(CO)x-1(THF)], thereby obviating many of the caveats… read more here.
Keywords: organometallic flow; chemistry; solvento complexes; flow chemistry ... See more keywords
Synthesis of proteins by automated flow chemistry
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.abb2491
Abstract: Fully synthetic whole proteins in reach Solid-phase peptide synthesis of homogeneous peptides longer than about 50 amino acids has been a long-standing challenge because of inefficient coupling and side reactions. Hartrampf et al. used an… read more here.
Keywords: automated flow; flow chemistry; amino acids; chemistry ... See more keywords
Flow Chemistry in Space-A Unique Opportunity to Perform Extraterrestrial Research
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Flow Chemistry"
DOI: 10.1556/1846.2017.00033
Abstract: For successful deep space exploration, a vast amount of chemistry-related challenges has to be overcome. In the last two decades, flow chemistry has matured enough to take the lead in performing chemical research in space.… read more here.
Keywords: flow chemistry; research; space; chemistry space ... See more keywords