Stopped-Flow NMR and Quantitative GPC Reveal Unexpected Complexities for the Mechanism of NHC-Catalyzed Lactide Polymerization
Sign Up to like & getrecommendations! Published in 2017 at "Macromolecules"
DOI: 10.1021/acs.macromol.6b02139
Abstract: Stopped-flow NMR spectroscopy provides the first direct, in situ observation of lactide epimerization during polymerization with the N-heterocyclic carbene organocatalyst 1,3-dimesitylimidazol-2-ylidene (IMes). Hexad analysis of the polymer microstructure using 13C NMR spectroscopy supports a chain-end-controlled… read more here.
Keywords: lactide polymerization; polymerization; stopped flow; mechanism ... See more keywords
Probing in vitro Release Kinetics of Long-Acting Injectable Nanosuspensions via Flow-NMR Spectroscopy.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.9b00958
Abstract: Novel treatment routes are emerging for an array of diseases and afflictions. Complex dosage forms, based on active pharmaceutical ingredients (APIs) with previously undesirable physicochemical characteristics, are becoming mainstream and actively pursued in various pipeline… read more here.
Keywords: long acting; vitro release; flow nmr; spectroscopy ... See more keywords