Deep Learning for Prediction and Optimization of Fast-Flow Peptide Synthesis
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DOI: 10.1021/acscentsci.0c00979
Abstract: The chemical synthesis of polypeptides involves stepwise formation of amide bonds on an immobilized solid support. The high yields required for efficient incorporation of each individual amino acid in the growing chain are often impacted… read more here.
Keywords: flow peptide; deprotection; deep learning; peptide synthesis ... See more keywords
Unveiling the Oxazolidine Character of Pseudoproline Derivatives by Automated Flow Peptide Chemistry
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DOI: 10.3390/ijms25084150
Abstract: Pseudoproline derivatives such as Thr(ΨPro)-OH are commonly used in peptide synthesis to reduce the likelihood of peptide aggregation and to prevent aspartimide (Asi) formation during the synthesis process. In this study, we investigate notable by-products… read more here.
Keywords: chemistry; pseudoproline; peptide chemistry; flow peptide ... See more keywords