A Modular, Argon-Driven Flow Platform for Natural Product Synthesis and Late-Stage Transformations.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c00661
Abstract: A modular flow platform for natural product synthesis was designed. To access different reaction setups with a maximum of flexibility, interchangeable 3D-printed components serve as backbone. By switching from liquid- to gas-driven flow, reagent and… read more here.
Keywords: product synthesis; platform natural; flow platform; natural product ... See more keywords
A flow platform for degradation-free CuAAC bioconjugation
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06551-0
Abstract: The Cu-catalyzed azide-alkyne cycloaddition (CuAAC) reaction is a cornerstone method for the ligation of biomolecules. However, undesired Cu-mediated oxidation and Cu-contamination in bioconjugates limits biomedical utility. Here, we report a generic CuAAC flow platform for… read more here.
Keywords: flow platform; degradation; cuaac reaction; cuaac ... See more keywords
Building up a Continuous Flow Platform as an Enabler to the Preparation of Intermediates on Kilogram Scale.
Sign Up to like & getrecommendations! Published in 2019 at "Chimia"
DOI: 10.2533/chimia.2019.828
Abstract: The following outlook describes the strategy we followed at Syngenta R&D to build and develop an effective flow chemistry platform which could fit a precise business purpose. In this account, we give insight into specific… read more here.
Keywords: flow platform; chemistry; platform enabler; continuous flow ... See more keywords
Characterization of a Centrifugal Microfluidic Orthogonal Flow Platform
Sign Up to like & getrecommendations! Published in 2022 at "Micromachines"
DOI: 10.3390/mi13030487
Abstract: To bring to bear the power of centrifugal microfluidics on vertical flow immunoassays, control of flow orthogonally through nanoporous membranes is essential. The on-disc approach described here leverages the rapid print-cut-laminate (PCL) disc fabrication and… read more here.
Keywords: characterization centrifugal; flow platform; flow; orthogonal flow ... See more keywords