Using extensional flow to reveal diverse aggregation landscapes for three IgG1 molecules
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DOI: 10.1002/bit.26543
Abstract: Monoclonal antibodies (mAbs) currently dominate the biopharmaceutical sector due to their potency and efficacy against a range of disease targets. These proteinaceous therapeutics are, however, susceptible to unfolding, mis‐folding, and aggregation by environmental perturbations. Aggregation… read more here.
Keywords: aggregation; flow reveal; extensional flow; reveal diverse ... See more keywords