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   Articles with "flt" as a keyword



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Role of 18F-FLT PET/CT in suspected recurrent or residual lymphoma: final results of a pilot prospective trial

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recommendations! Published in 2019 at "European Journal of Nuclear Medicine and Molecular Imaging"

DOI: 10.1007/s00259-019-04323-6

Abstract: PurposeTo evaluate the role of F-18-Fluorothymidine (FLT) PET/CT in lymphoma patients with suspected recurrent or residual disease.MethodsAdult lymphoma patients presenting with positive or equivocal F-18-FDG PET/CT at end-treatment or follow-up were prospectively addressed to an… read more here.

Keywords: lymphoma; flt pet; recurrent residual; flt ... See more keywords
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Triphosphate Prodrugs of the Anti-HIV-Active Compound 3'-Deoxy-3'-fluorothymidine (FLT).

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recommendations! Published in 2022 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.2c00665

Abstract: 3'-Fluoro-3'-deoxythymidine (FLT) was identified as one of the most potent inhibitors of human immunodeficiency virus (HIV) replication. However, FLT also showed severe toxicity so that it was abundant as a potential chemotherapeutic agent. Here, we… read more here.

Keywords: triphosphate prodrugs; flt; hiv active; prodrugs anti ... See more keywords

Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion.

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recommendations! Published in 2018 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.8b10320

Abstract: The receptor tyrosine kinase FLT-3 is frequently mutated in acute myeloid leukemia; however, current small molecule inhibitors suffer from limited efficacy in the clinic. Conversion of a FLT-3 inhibitor (quizartinib) into a proteolysis targeting chimera… read more here.

Keywords: targeting chimera; flt; flt itd; proteolysis targeting ... See more keywords
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Federated Learning with Taskonomy for Non-IID Data

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recommendations! Published in 2022 at "IEEE transactions on neural networks and learning systems"

DOI: 10.1109/tnnls.2022.3152581

Abstract: Classical federated learning approaches incur significant performance degradation in the presence of non-independent and identically distributed (non-IID) client data. A possible direction to address this issue is forming clusters of clients with roughly IID data.… read more here.

Keywords: non iid; federated learning; learning taskonomy; taskonomy non ... See more keywords
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RNA activating-double stranded RNA targeting flt-1 promoter inhibits endothelial cell proliferation through soluble FLT-1 upregulation

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recommendations! Published in 2018 at "PLoS ONE"

DOI: 10.1371/journal.pone.0193590

Abstract: Short-activating RNA (saRNA), which targets gene promoters, has been shown to increase the target gene expression. In this study, we describe the use of an saRNA (Flt a-1) to target the flt-1 promoter, leading to… read more here.

Keywords: flt promoter; flt; endothelial cell; rna ... See more keywords
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Vascular Endothelial Growth Factor Receptor, fms-Like Tyrosine Kinase-1 (Flt-1), as a Novel Binding Partner for SARS-CoV-2 Spike Receptor-Binding Domain

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recommendations! Published in 2022 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2022.906063

Abstract: Angiotensin-converting enzyme 2 (ACE2) and neuropilin 1, a vascular endothelial growth factor (VEGF) receptor, were identified to bind to the SARS-CoV-2 spike receptor-binding domain (spike RBD). In silico analysis based on 3D structure, multiple sequence… read more here.

Keywords: flt; rbd; rspike rbd; receptor ... See more keywords
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PlGF/FLT-1 deficiency leads to reduced STAT3-C/EBPβ signaling and aberrant polarization in decidual macrophages during early spontaneous abortion

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recommendations! Published in 2023 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2023.1061949

Abstract: Introduction Dysregulated macrophage polarization (excessive M1-like or limited M2-like macrophages) in the early decidua contributes to allogeneic fetal rejection and thus early spontaneous abortion. However, the modulators of M1/M2 balance at the early maternal-fetal interface… read more here.

Keywords: spontaneous abortion; flt; abortion; plgf ... See more keywords