Combined inhibition of PI3Kδ and FLT3 signaling exerts synergistic antitumor activity and overcomes acquired drug resistance in FLT3-activated acute myeloid leukemia.
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DOI: 10.1016/j.canlet.2018.01.071
Abstract: PI3Kδ and FLT3 are frequently activated in acute myeloid leukemia (AML) and have been implicated as potential therapeutic targets. In this report, we demonstrate that combined inhibition of PI3Kδ and FLT3 exerts synergistic antitumor activity… read more here.
Keywords: flt3 activated; pi3k flt3; combined inhibition; flt3 ... See more keywords