Improved Outcomes Among Newly Diagnosed Patients with FLT3-ITD Mutated AML Treated with Contemporary Therapy: Revisiting the ELN Adverse Risk Classification.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of hematology"
DOI: 10.1002/ajh.26451
Abstract: Mutations in in fms-like tyrosine kinase 3 (FLT3) gene are common genomic alterations in acute myeloid leukemia (AML). FLT3 internal tandem duplication mutations (FLT3-ITD) have consistently been shown to be adversely prognostic, particularly those with… read more here.
Keywords: eln adverse; patients flt3; adverse risk; flt3 mutations ... See more keywords
Hematologists Demonstrate Sub-Optimal Knowledge of FLT3 Mutations in Acute Myeloid Leukemia
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DOI: 10.1182/blood-2018-99-115409
Abstract: Background: The objective of this study was to assess current clinical practices of hematologist/oncologist (hem/onc) specialists related to FLT3 mutations and FLT3 inhibitors used in acute myeloid leukemia (AML), in order to identify knowledge, competency,… read more here.
Keywords: hem onc; knowledge; flt3; flt3 mutations ... See more keywords
Absence of FLT3 mutations in Iranian adult T-cell leukemia/lymphoma patients
Sign Up to like & getrecommendations! Published in 2018 at "Medical Journal of the Islamic Republic of Iran"
DOI: 10.14196/mjiri.32.47
Abstract: Background: Adult T cell leukemia lymphoma (ATLL) is a rare disease, significantly linked to the infection by the human T-cell lymphotropic virus 1(HTLV-1). ATLL is typically preceded by decades of clinical latency during which infected… read more here.
Keywords: cell leukemia; leukemia lymphoma; adult cell; atll ... See more keywords
Obesity is a risk factor for acute promyelocytic leukemia: evidence from population and cross-sectional studies and correlation with FLT3 mutations and polyunsaturated fatty acid metabolism
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DOI: 10.3324/haematol.2019.223925
Abstract: Obesity correlates with hematologic malignancies including leukemias, but risk of specific leukemia subtypes like acute promyelocytic leukemia and underlying molecular mechanisms are poorly understood. We explored multiple datasets for correlation between leukemia, body mass index… read more here.
Keywords: leukemias; cross sectional; promyelocytic leukemia; flt3 mutations ... See more keywords
Profiling FLT3 Mutations in Mexican Acute Myeloid Leukemia Pediatric Patients: Impact on Overall Survival
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DOI: 10.3389/fped.2020.00586
Abstract: Background: Acute myeloid leukemia (AML) is the second most frequent leukemia in childhood. The FLT3 gene participates in hematopoietic stem cell proliferation. FLT3 mutations are recurrent in AML and influence prognosis. In Mexican pediatric AML… read more here.
Keywords: aml patients; myeloid leukemia; flt3 mutations; acute myeloid ... See more keywords
Prognostic Relevance of NPM1 and FLT3 Mutations in Acute Myeloid Leukaemia, Longterm Follow-Up—A Single Center Experience
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DOI: 10.3390/cancers14194716
Abstract: Simple Summary In acute myeloid leukemia, molecular genetics abnormalities, particularly NPM1 and FLT3 mutations, have a recognized prognostic role in the ELN risk classification and guide treatment decisions, especially since the availability of FLT3-targeted drugs.… read more here.
Keywords: flt3; itd; npm1 flt3; survival ... See more keywords