Improved Outcomes Among Newly Diagnosed Patients with FLT3-ITD Mutated AML Treated with Contemporary Therapy: Revisiting the ELN Adverse Risk Classification.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of hematology"
DOI: 10.1002/ajh.26451
Abstract: Mutations in in fms-like tyrosine kinase 3 (FLT3) gene are common genomic alterations in acute myeloid leukemia (AML). FLT3 internal tandem duplication mutations (FLT3-ITD) have consistently been shown to be adversely prognostic, particularly those with… read more here.
Keywords: eln adverse; patients flt3; adverse risk; flt3 mutations ... See more keywords
Clinical and genetic characteristics predict outcomes of acute myeloid leukemia patients with FLT3 mutations receiving venetoclax‐based therapy
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DOI: 10.1002/cam4.6885
Abstract: Acute myeloid leukemia (AML) is a heterogeneous disease, and its heterogeneity is associated with treatment response. Despite the demonstrated success of venetoclax (VEN)‐based therapy for AML, the effect of FLT3 mutations on the efficacy of… read more here.
Keywords: acute myeloid; flt3 mutations; based therapy; venetoclax ... See more keywords
Discovery of a Potent FLT3 Inhibitor (E)-4-(3-(3-Fluoro-4-(morpholinomethyl)styryl)-1H-indazol-6-yl)pyridin-2-amine for the Treatment of Acute Myeloid Leukemia with Multiple FLT3 Mutations.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.5c00698
Abstract: Targeting FLT3 genetic alterations has emerged as a promising therapeutic approach for AML. However, the rapid emergence of resistance to FLT3 inhibitors has severely curtailed their clinical utility. Herein, we developed a series of (E)-4-(3-arylvinyl-1H-indazol-6-yl)pyridin-2-amine… read more here.
Keywords: flt3; flt3 inhibitor; flt3 mutations; potent flt3 ... See more keywords
Hematologists Demonstrate Sub-Optimal Knowledge of FLT3 Mutations in Acute Myeloid Leukemia
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DOI: 10.1182/blood-2018-99-115409
Abstract: Background: The objective of this study was to assess current clinical practices of hematologist/oncologist (hem/onc) specialists related to FLT3 mutations and FLT3 inhibitors used in acute myeloid leukemia (AML), in order to identify knowledge, competency,… read more here.
Keywords: hem onc; knowledge; flt3; flt3 mutations ... See more keywords
Impact of c-KIT and FLT3 mutations on survival outcomes in core-binding factor acute myeloid leukemia: A systematic review and meta-analysis
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DOI: 10.1182/blood-2025-7006
Abstract: Background: Core-binding factor acute myeloid leukemia (CBF-AML) is generally considered a favorable-risk subtype; however, prognosis varies based on co-occurring genetic alterations. Among these, c-KIT and FLT3 mutations have been proposed as adverse prognostic markers, though… read more here.
Keywords: flt3; kit flt3; analysis; flt3 mutations ... See more keywords
FLT3 testing and guideline concordance in Acute Myeloid Leukemia across an Indiana health system
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DOI: 10.1182/blood-2025-7955
Abstract: Background: FLT3 mutations occur in approximately 30% of patients with acute myeloid leukemia (AML) and are associated with an adverse prognosis. Current guidelines recommend FLT3 mutation testing at diagnosis to inform risk stratification and guide… read more here.
Keywords: treatment; flt3 testing; flt3; flt3 mutations ... See more keywords
Absence of FLT3 mutations in Iranian adult T-cell leukemia/lymphoma patients
Sign Up to like & getrecommendations! Published in 2018 at "Medical Journal of the Islamic Republic of Iran"
DOI: 10.14196/mjiri.32.47
Abstract: Background: Adult T cell leukemia lymphoma (ATLL) is a rare disease, significantly linked to the infection by the human T-cell lymphotropic virus 1(HTLV-1). ATLL is typically preceded by decades of clinical latency during which infected… read more here.
Keywords: cell leukemia; leukemia lymphoma; adult cell; atll ... See more keywords
Obesity is a risk factor for acute promyelocytic leukemia: evidence from population and cross-sectional studies and correlation with FLT3 mutations and polyunsaturated fatty acid metabolism
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DOI: 10.3324/haematol.2019.223925
Abstract: Obesity correlates with hematologic malignancies including leukemias, but risk of specific leukemia subtypes like acute promyelocytic leukemia and underlying molecular mechanisms are poorly understood. We explored multiple datasets for correlation between leukemia, body mass index… read more here.
Keywords: leukemias; cross sectional; promyelocytic leukemia; flt3 mutations ... See more keywords
Profiling FLT3 Mutations in Mexican Acute Myeloid Leukemia Pediatric Patients: Impact on Overall Survival
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DOI: 10.3389/fped.2020.00586
Abstract: Background: Acute myeloid leukemia (AML) is the second most frequent leukemia in childhood. The FLT3 gene participates in hematopoietic stem cell proliferation. FLT3 mutations are recurrent in AML and influence prognosis. In Mexican pediatric AML… read more here.
Keywords: aml patients; myeloid leukemia; flt3 mutations; acute myeloid ... See more keywords
Prognostic Relevance of NPM1 and FLT3 Mutations in Acute Myeloid Leukaemia, Longterm Follow-Up—A Single Center Experience
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DOI: 10.3390/cancers14194716
Abstract: Simple Summary In acute myeloid leukemia, molecular genetics abnormalities, particularly NPM1 and FLT3 mutations, have a recognized prognostic role in the ELN risk classification and guide treatment decisions, especially since the availability of FLT3-targeted drugs.… read more here.
Keywords: flt3; itd; npm1 flt3; survival ... See more keywords
Distinct FLT3 Pathways Gene Expression Profiles in Pediatric De Novo Acute Lymphoblastic and Myeloid Leukemia with FLT3 Mutations: Implications for Targeted Therapy
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms25179581
Abstract: Activating FLT3 mutations plays a crucial role in leukemogenesis, but identifying the optimal candidates for FLT3 inhibitor therapy remains controversial. This study aims to explore the impacts of FLT3 mutations in pediatric acute lymphoblastic leukemia… read more here.
Keywords: flt3; acute lymphoblastic; flt3 mutations; expression ... See more keywords