Assessment of Pharmacokinetic Interaction Between Letermovir and Fluconazole in Healthy Participants
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DOI: 10.1002/cpdd.852
Abstract: Letermovir is a prophylactic agent for cytomegalovirus infection and disease in adult cytomegalovirus‐seropositive recipients of allogeneic hematopoietic stem cell transplant. As the antifungal agent fluconazole is administered frequently in transplant recipients, a drug–drug interaction study… read more here.
Keywords: pharmacokinetic interaction; interaction letermovir; assessment pharmacokinetic; coadministration fluconazole ... See more keywords
Emerging issue of fluconazole-resistant candidemia in a tertiary care hospital of southern italy: time for antifungal stewardship program.
Sign Up to like & getrecommendations! Published in 2021 at "Journal de mycologie medicale"
DOI: 10.1016/j.mycmed.2021.101206
Abstract: An increased number of patients is at risk of Candida spp. bloodstream infection (CBSI) in modern medicine. Moreover, the rising of antifungal resistance (AR) was recently reported. All consecutive CBSI occurred in our Hospital (consisting… read more here.
Keywords: antifungal stewardship; cbsi; hospital; fluconazole ... See more keywords
Bleeding interaction between fluconazole and warfarin
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DOI: 10.1016/s0140-6736(18)32217-7
Abstract: e9 A 71-year-old woman with paroxysmal atrial fibrillation being treated with warfarin 3·75 mg/day presented at our hospital with a 5-day history of increasing swelling in her neck, sialorrhoea, and difficulty swallowing. 1 week earlier,… read more here.
Keywords: fluconazole warfarin; warfarin; bleeding interaction; interaction fluconazole ... See more keywords
Epidemiology and Molecular Basis of Resistance to Fluconazole Among Clinical Candida parapsilosis Isolates in Kuwait.
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DOI: 10.1089/mdr.2016.0336
Abstract: Fluconazole resistance among clinical Candida parapsilosis isolates is an emerging problem in many countries, including Kuwait. Resistance to fluconazole is mediated by amino acid substitutions in ERG11 and/or by overexpression of efflux pumps MDR1 and… read more here.
Keywords: epidemiology; resistance; fluconazole; among clinical ... See more keywords
Rapid Tetra-Primer Amplification Refractory Mutation System-Polymerase Chain Reaction Protocol for Detection of Y132F Mutation in Fluconazole Resistant Candida parapsilosis
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DOI: 10.1089/mdr.2023.0198
Abstract: There is an emerging fluconazole resistance in Candida parapsilosis in recent years. The leading mechanism causing azole resistance in C. parapsilosis is the Y132F codon alteration in the ERG11 gene which encodes the target enzyme… read more here.
Keywords: resistance; parapsilosis; detection y132f; mutation ... See more keywords
Zap1 is required for Candida glabrata response to fluconazole.
Sign Up to like & getrecommendations! Published in 2022 at "FEMS yeast research"
DOI: 10.1093/femsyr/foab068
Abstract: The increasing prevalence of fluconazole-resistant clinical isolates of Candida spp. strongly hinders the widespread use of the drug. To tackle this problem, great efforts have been made to fully understand the fungal response to fluconazole.… read more here.
Keywords: zap1; response fluconazole; drug; fluconazole ... See more keywords
Effect of fluconazole prophylaxis on Candida fluconazole susceptibility in premature infants
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DOI: 10.1093/jac/dky353
Abstract: Objectives Extremely premature infants are at high risk of developing invasive candidiasis; fluconazole prophylaxis is safe and effective for reducing invasive candidiasis in this population but further study is needed. We sought to better understand… read more here.
Keywords: candida; premature infants; period; fluconazole ... See more keywords
Emergence of clonal fluconazole-resistant Candida parapsilosis clinical isolates in a multicentre laboratory-based surveillance study in India
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkz029
Abstract: Objectives The emergence of fluconazole resistance in Candida parapsilosis healthcare-associated infections has recently been increasingly reported. Antifungal susceptibility profiles and mechanisms of fluconazole resistance in C. parapsilosis (n = 199) from nine hospitals in India collected over… read more here.
Keywords: candida parapsilosis; parapsilosis; fluconazole resistant; non susceptible ... See more keywords
Candida tropicalis morphotypes show altered cellular structure and gene expression pre- and post-exposure to fluconazole.
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DOI: 10.1093/mmy/myae110
Abstract: A feature of Candida tropicalis is its ability to undergo phenotypic switching that can affect antifungal sensitivity and virulence traits. Here, we investigated the effect of switching on alterations at the cellular structure level of… read more here.
Keywords: tropicalis; tropicalis morphotypes; expression; exposure ... See more keywords
Population Pharmacokinetics and Cerebrospinal Fluid Penetration of Fluconazole in Adults with Cryptococcal Meningitis
Sign Up to like & getrecommendations! Published in 2018 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00885-18
Abstract: Robust population pharmacokinetic (PK) data for fluconazole are scarce. The variability of fluconazole penetration into the central nervous system (CNS) is not known. ABSTRACT Robust population pharmacokinetic (PK) data for fluconazole are scarce. The variability… read more here.
Keywords: penetration; compartment; cryptococcal meningitis; fluconazole ... See more keywords
New Data on the In Vitro Activity of Fenticonazole against Fluconazole-Resistant Candida Species
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DOI: 10.1128/aac.01459-20
Abstract: Despite the advent of echinocandins and newer triazoles (voriconazole, posaconazole, and isavuconazole) (1), fluconazole (FLZ) remains an important component of today’s antifungal arsenal, particularly for treatment of Candida infections (2, 3).… read more here.
Keywords: new data; candida; data vitro; activity fenticonazole ... See more keywords