Predicting the Effects of Different Triazole Antifungal Agents on the Pharmacokinetics of Tamoxifen
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DOI: 10.1208/s12249-018-1219-5
Abstract: Tamoxifen is an antiestrogen drug that is widely used in the adjuvant chemotherapy of estrogen receptor-α (ERα)-positive breast cancer. Chemotherapy could suppress immune function in breast cancer patients, which may cause invasive fungal infections (IFIs).… read more here.
Keywords: itraconazole tamoxifen; itraconazole; tamoxifen; voriconazole fluconazole ... See more keywords
Differential effects of ketoconazole, fluconazole, and itraconazole on the pharmacokinetics of pyrotinib in vitro and in vivo
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DOI: 10.3389/fphar.2022.962731
Abstract: It has been reported that drug-drug interactions (DDIs) can affect the pharmacokinetics and pharmacodynamics of various oral drugs. To better understand the effects of azole antifungal drugs (ketoconazole, fluconazole, and itraconazole) on pyrotinib’s pharmacokinetics, DDIs… read more here.
Keywords: ketoconazole fluconazole; pyrotinib vitro; fluconazole itraconazole; vitro vivo ... See more keywords