Multilocus sequence analyses reveal extensive diversity and multiple origins of fluconazole resistance in Candida tropicalis from tropical China
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep42537
Abstract: Candida tropicalis is among the most prevalent human pathogenic yeast species, second only to C. albicans in certain geographic regions such as East Asia and Brazil. However, compared to C. albicans, relatively little is known… read more here.
Keywords: fluconazole resistance; multiple origins; origins fluconazole; candida tropicalis ... See more keywords
RNAi machinery regulates nutrient metabolism and fluconazole resistance in the pathogenic fungus Cryptococcus deneoformans.
Sign Up to like & getrecommendations! Published in 2022 at "Medical mycology"
DOI: 10.1093/mmy/myac095
Abstract: The RNAi machinery has been extensively studied in plant and animal cells for their crucial roles in regulation of genome function. However, the potential roles of RNAi in controlling fungal growth and development have been… read more here.
Keywords: cryptococcus deneoformans; fluconazole resistance; resistance; rnai machinery ... See more keywords
168. Creation and Internal Validation of a Clinical Predictive Model for Fluconazole Resistance in Patients with Candida Bloodstream Infection
Sign Up to like & getrecommendations! Published in 2020 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofaa439.212
Abstract: IDSA guidelines on candidemia recommend fluconazole as first-line therapy in patients considered low risk for fluconazole resistant infections. However, there is currently no mechanism to determine risk of resistance, and most community hospitals cannot perform… read more here.
Keywords: fluconazole resistance; patients candida; candida bloodstream; bloodstream infection ... See more keywords
Vaginal Candida albicans: High Frequency of in Vitro Fluconazole Resistance in a Select Population—A Brief Note
Sign Up to like & getrecommendations! Published in 2022 at "Sexually Transmitted Diseases"
DOI: 10.1097/olq.0000000000001730
Abstract: In this select population, we found a high frequency of in vitro fluconazole resistance in vaginal Candida albicans. Resistance did not reliably predict future susceptibility. Abstract Among clinician-ordered vaginal cultures positive for Candida albicans, 30%… read more here.
Keywords: high frequency; fluconazole resistance; select population; resistance ... See more keywords
A longitudinal study on fluconazole resistance in Candida albicans vaginal isolates
Sign Up to like & getrecommendations! Published in 2023 at "Mycoses"
DOI: 10.1111/myc.13582
Abstract: Recurrent vulvovaginal candidiasis (RVVC), despite its worldwide prevalence, has limited treatment options; and a long‐term prophylactic regimen utilising fluconazole is the dominant choice. read more here.
Keywords: resistance candida; study fluconazole; fluconazole resistance; albicans vaginal ... See more keywords
Clonal Spread of Candida glabrata Bloodstream Isolates and Fluconazole Resistance Affected by Prolonged Exposure: a 12-Year Single-Center Study in Belgium
Sign Up to like & getrecommendations! Published in 2018 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00591-18
Abstract: ABSTRACT Candida glabrata is a major cause of candidemia in immunocompromised patients and is characterized by a high-level of fluconazole resistance. In the present study, the acquisition of antifungal resistance and potential clonal spread of… read more here.
Keywords: fluconazole resistance; glabrata; study; resistance ... See more keywords
Evolution of Fluconazole Resistance Mechanisms and Clonal Types of Candida parapsilosis Isolates from a Tertiary Care Hospital in South Korea
Sign Up to like & getrecommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00889-22
Abstract: We investigated the evolution of fluconazole resistance mechanisms and clonal types of Candida parapsilosis isolates from a tertiary care hospital in South Korea. A total of 45 clinical isolates, including 42 collected between 2017 and… read more here.
Keywords: parapsilosis isolates; fluconazole resistance; resistance; evolution ... See more keywords
Mathematical Modeling of Fluconazole Resistance in the Ergosterol Pathway of Candida albicans
Sign Up to like & getrecommendations! Published in 2022 at "mSystems"
DOI: 10.1128/msystems.00691-22
Abstract: Candidiasis is reported to be the most common fungal infection in the critical care setting, and it is caused by a commensal pathogen belonging to the genus Candida, the most common species of which is… read more here.
Keywords: fluconazole; candidiasis; fluconazole resistance; ergosterol pathway ... See more keywords
SWL-1 Reverses Fluconazole Resistance in Candida albicans by Regulating the Glycolytic Pathway
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2020.572608
Abstract: Candida albicans is a ubiquitous clinical fungal pathogen. Prolonged use of the first-line antifungal agent fluconazole (FLC) has intensified fungal resistance and limited its effectiveness for the treatment of fungal infections. The combined administration of… read more here.
Keywords: fluconazole resistance; candida albicans; resistance; reverses fluconazole ... See more keywords
Epidemiology of Candidemia and Fluconazole Resistance in an ICU before and during the COVID-19 Pandemic Era
Sign Up to like & getrecommendations! Published in 2022 at "Antibiotics"
DOI: 10.3390/antibiotics11060771
Abstract: The objectives of this study were to investigate the incidence of candidemia, as well as the factors associated with Candida species distribution and fluconazole resistance, among patients admitted to the intensive care unit (ICU) during… read more here.
Keywords: icu covid; candidemia; fluconazole resistance; epidemiology ... See more keywords
Fructose Induces Fluconazole Resistance in Candida albicans through Activation of Mdr1 and Cdr1 Transporters
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22042127
Abstract: Candida albicans is a pathogenic fungus that is increasingly developing multidrug resistance (MDR), including resistance to azole drugs such as fluconazole (FLC). This is partially a result of the increased synthesis of membrane efflux transporters… read more here.
Keywords: fluconazole resistance; induces fluconazole; fructose induces; candida albicans ... See more keywords