Crystal anisotropy explains structure‐mechanics impact on tableting performance of flufenamic acid polymorphs
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2018.09.006
Abstract: Graphical abstract Figure. No Caption available. Abstract Anisotropic features with other crystallographic properties like d‐spacing, and attachment energy (Eatt) can predict material performance during the secondary pharmaceutical processing. A newly developed state‐of‐the‐art compression cell lodged… read more here.
Keywords: form iii; form; tableting performance; performance ... See more keywords
Monoacyl-phospatidylcholine nanostructured lipid carriers: Influence of lipid and surfactant content on in vitro skin permeation of flufenamic acid and fluconazole
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2017.08.016
Abstract: Abstract Monoacyl-phosphatidylcholine (MAPL) is a skin-friendly phospholipid emulsifier that has successfully been employed for development of microemulsions. Its potential for stabilising particulate lipid drug carriers has not been explored so far. Thus, the aim of… read more here.
Keywords: content; skin permeation; vitro; flufenamic acid ... See more keywords
Insight into Flufenamic Acid Cocrystal Dissolution in the Presence of a Polymer in Solution: from Single Crystal to Powder Dissolution.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.7b00712
Abstract: Effects of three polymers, polyethylene glycol (PEG), polyvinylpyrrolidone (PVP), and copolymer of vinylpyrrolidone/vinyl acetate (PVP-VA), on the dissolution behavior of the cocrystals of flufenamic acid with theophylline (FFA-TP CO) and nicotinamide (FFA-NIC CO) were investigated… read more here.
Keywords: dissolution; microscopy; surface; single crystal ... See more keywords
Synthesis, characterization, and biological activities of a Cu(II) complex with the non-steroidal antiinflammatory drug flufenamic acid
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Coordination Chemistry"
DOI: 10.1080/00958972.2017.1386303
Abstract: Abstract [CuII(L)2.C12H10N2] with flufenamic acid (HL=C14H10F3NO2) and phenanthroline (C12H10N2O) was synthesized and characterized by C, H and N elemental analysis, single-crystal X-ray diffraction and, IR spectra. The urease inhibitory and antibacterial activities of the complex… read more here.
Keywords: characterization biological; activities complex; spectroscopy; flufenamic acid ... See more keywords
Investigation of the Spatial Structure of Flufenamic Acid in Supercritical Carbon Dioxide Media via 2D NOESY
Sign Up to like & getrecommendations! Published in 2023 at "Materials"
DOI: 10.3390/ma16041524
Abstract: The search for new forms of already known drug compounds is an urgent problem of high relevance as more potent drugs with fewer side effects are needed. The trifluoromethyl group in flufenamic acid renders its… read more here.
Keywords: structure; supercritical carbon; carbon dioxide; drug compounds ... See more keywords
Role of Cyclodextrins and Drug Solid State Properties on Flufenamic Acid Dissolution Performance from Tablets
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14020284
Abstract: Flufenamic acid (FFA) is a non-steroidal anti-inflammatory drug characterised by a low solubility and problems of variable dissolution rate and bio-inequivalence. Different FFA batches, obtained by different suppliers, showed different powder characteristics (particle size, shape… read more here.
Keywords: dissolution; solid state; drug; dissolution performance ... See more keywords