Solidification of SMEDDS by fluid bed granulation and manufacturing of fast drug release tablets.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.119377
Abstract: Solidification of self-microemulsifying drug delivery systems (SMEDDS) is a rising experimental field with important potential for pharmaceutical industry, however fluid-bed granulation with SMEDDS is yet an unexplored solidification technique. The aim of the study was… read more here.
Keywords: granulation; fluid bed; bed granulation; drug ... See more keywords
continuous twin screw granulation and fluid bed drying: a mechanistic scaling approach focusing optimal tablet properties.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.119509
Abstract: This study provides the results of investigation on scaling approaches for three differently-sized continuous granulation lines, each consisting of a twin screw wet granulation process and a continuous fluid bed drying process. To check the… read more here.
Keywords: scaling approach; granulation; fluid bed; twin screw ... See more keywords
Moisture soft sensor for batch fluid bed dryers: A practical approach
Sign Up to like & getrecommendations! Published in 2018 at "Powder Technology"
DOI: 10.1016/j.powtec.2017.11.056
Abstract: Abstract Moisture content is a critical quality attribute in drying of pharmaceutical formulations. This paper proposes a hybrid soft sensor for online real-time estimation of the product moisture in batch fluid bed dryers. Major applications… read more here.
Keywords: bed dryers; moisture; soft sensor; fluid bed ... See more keywords
Use of machine learning tool to elucidate and characterize the growth mechanism of an in-situ fluid bed melt granulation
Sign Up to like & getrecommendations! Published in 2018 at "Powder Technology"
DOI: 10.1016/j.powtec.2018.03.052
Abstract: Abstract The aim of this work is to follow the agglomeration mechanism of an in situ Fluid Bed Melt Granulation (FBMG) by means of machine learning with Artificial Neural Network (ANN) modelling. Scanning Electron Microscopy… read more here.
Keywords: situ fluid; fluid bed; mechanism situ; melt granulation ... See more keywords
Orthogonal Redundant Monitoring of a New Continuous Fluid-Bed Dryer for Pharmaceutical Processing by Means of Mass and Energy Balance Calculations and Spectroscopic Techniques.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2018.12.028
Abstract: In line with the ongoing shift from batch to continuous pharmaceutical production of solid oral dosage forms, a novel continuous fluid-bed dryer was developed. The forced feed nature of the Glatt GPCG2 CM fluid-bed dryer… read more here.
Keywords: continuous fluid; fluid bed; energy; fluid ... See more keywords
In situ fabrication of silver-based nanostructures using electron beam
Sign Up to like & getrecommendations! Published in 2018 at "CrystEngComm"
DOI: 10.1039/c7ce02244a
Abstract: Herein, electron beam irradiation (EBI) was employed to in situ construct Ag-based micro/nanostructures. The composition of AgX@Ag (X = Cl−, Br−, etc.) composites and the size/morphology of silver nanoparticles (Ag-NPs) were tuned by adjusting the… read more here.
Keywords: silver; electron beam; fluid bed; situ fabrication ... See more keywords
Optimization of the coating process of minitablets in two different lab-scale fluid bed systems
Sign Up to like & getrecommendations! Published in 2019 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2019.1698596
Abstract: Abstract The optimization of the coating process for minitablets is extremely important in fluidized bed systems, and allows knowledge acquisition about the process for modern multiparticulate forms. The coating of minitablets allows the development of… read more here.
Keywords: bed systems; fluid bed; coating process; optimization coating ... See more keywords
Surface Modification of lactose carrier particles using a fluid bed coater to improve fine particle fraction for dry powder inhalers
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2023.2171434
Abstract: Abstract Surface roughness of carrier particles can impact dry powder inhaler (DPI) performance. There are opposing views on the effect of roughness on DPI performance. Hence, a systematic approach is needed to modify carrier surfaces… read more here.
Keywords: carrier; fluid bed; surface; carrier particles ... See more keywords
Scale-up of Fluid Bed Granulation Using a Scale-Independent Parameter and a Process Model.
Sign Up to like & getrecommendations! Published in 2021 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-021-02013-x
Abstract: A practice-based approach for the scale-up of fluid bed granulation in the context of drug product development is presented and evaluated in this work in the context of clinical drug product manufacturing development. The approach… read more here.
Keywords: fluid bed; bed granulation; process; process model ... See more keywords
IN-LINE FLUID BED GRANULATION MONITORING BY NIR SPECTROSCOPY. METHOD DEVELOPMENT AND VALIDATION
Sign Up to like & getrecommendations! Published in 2019 at "FARMACIA"
DOI: 10.31925/farmacia.2019.2.8
Abstract: This study describes the development of an in-line NIR fluid bed granulation monitoring method, evaluating the capacities of a Viavi microNIRTM spectrometer during the process. For this purpose, an experimental design was set up, having… read more here.
Keywords: spectroscopy; process; monitoring; granulation ... See more keywords
The Influence of Equipment Design and Process Parameters on Granule Breakage in a Semi-Continuous Fluid Bed Dryer after Continuous Twin-Screw Wet Granulation
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics13020293
Abstract: The drying unit of a continuous from-powder-to-tablet manufacturing line based on twin-screw granulation (TSG) is a crucial intermediate process step to achieve the desired tablet quality. Understanding the size reduction of pharmaceutical granules before, during,… read more here.
Keywords: granulation; fluid bed; twin screw; breakage ... See more keywords