Validation of Rapi-Fluor method for glycan profiling and application to commercial antibody drugs.
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DOI: 10.1016/j.talanta.2019.01.093
Abstract: N-glycans influence the activity of antibody drugs such as antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). Thus, glycan profiling is considered a critical quality attribute (CQA) and requires routine and comprehensive monitoring. In this… read more here.
Keywords: glycan profiling; antibody drugs; method; fluor method ... See more keywords