Fluorescence-Guided Surgery for Assessing Margins in Head and Neck Cancer: A Review.
Sign Up to like & getrecommendations! Published in 2025 at "JAMA surgery"
DOI: 10.1001/jamasurg.2025.1815
Abstract: Importance Head and neck squamous cell cancer (HNSCC) is associated with a higher positive margin rate compared with most other cancers in surgical oncology. This rate has remained stagnant over the past 3 decades. Fluorescence-guided… read more here.
Keywords: surgery; cancer; head neck; fluorescence ... See more keywords
Fluorescence‐Guided Spatial Drug Screening in 3D Colorectal Cancer Spheroids
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202400203
Abstract: The limited recapitulation of critical cancer features in 2D cultures causes poor translatability of preclinical results from in vitro assays to in vivo tumor models. This contributes to slow drug development with a low success… read more here.
Keywords: colorectal cancer; cancer; crc spheroids; drug ... See more keywords
Fluorescence-guided laser lithotripsy: Estimation of the potential effectiveness and safety increase based on first clinical data.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of biophotonics"
DOI: 10.1002/jbio.202300044
Abstract: In clinically approved laser lithotripsy systems, there is no automatic monitoring of fiber position to date. We investigated whether detecting stone autofluorescence, excited by a green aiming beam, is possible via the fiber during fragmentation… read more here.
Keywords: estimation potential; lithotripsy estimation; guided laser; laser lithotripsy ... See more keywords
State of the art medical devices for fluorescence-guided surgery (FGS): technical review and future developments
Sign Up to like & getrecommendations! Published in 2024 at "Surgical Endoscopy"
DOI: 10.1007/s00464-024-11236-5
Abstract: Medical devices for fluorescence-guided surgery (FGS) are becoming available at a fast pace. The main challenge for surgeons lies in the lack of in-depth knowledge of optical imaging, different technical specifications and poor standardisation, and… read more here.
Keywords: surgery; devices fluorescence; fluorescence; guided surgery ... See more keywords
SGM-101: An innovative near-infrared dye-antibody conjugate that targets CEA for fluorescence-guided surgery.
Sign Up to like & getrecommendations! Published in 2017 at "Surgical oncology"
DOI: 10.1016/j.suronc.2017.03.002
Abstract: PURPOSE Fluorescence-guided surgery (FGS) provides surgeons with new opportunities to improve real-time cancer nodule detection and tumor margin visualization. Currently, the most important challenge in this field is the development of fluorescent dyes that specifically… read more here.
Keywords: sgm 101; antibody; fluorescence guided; guided surgery ... See more keywords
Chemical Decrosslinking-Based Peptide Characterization of Formaldehyde-Fixed Rat Pancreas Using Fluorescence-Guided Single-Cell Mass Spectrometry.
Sign Up to like & getrecommendations! Published in 2023 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.3c00612
Abstract: Approaches for the characterization of proteins/peptides in single cells of formaldehyde-fixed (FF) tissues via mass spectrometry (MS) are still under development. The lack of a general method for selectively eliminating formaldehyde-induced crosslinking is a major… read more here.
Keywords: cell; mass spectrometry; formaldehyde fixed; fluorescence guided ... See more keywords
Preclinical Evaluation of a Humanized, Near-Infrared Fluorescent Antibody for Fluorescence-Guided Surgery of MUC16-Expressing Pancreatic Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00203
Abstract: Surgery remains the only potentially curative treatment option for pancreatic cancer, but resections are made more difficult by infiltrative disease, proximity of critical vasculature, peritumoral inflammation, and dense stroma. Surgeons are limited to tactile and… read more here.
Keywords: pancreatic cancer; fluorescence guided; cancer; guided surgery ... See more keywords
High-Contrast Detection of Somatostatin Receptor Subtype-2 for Fluorescence-Guided Surgery
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00583
Abstract: Dye design can influence the ability of fluorescently labeled imaging agents to generate tumor contrast and has become an area of significant interest in the field of fluorescence-guided surgery (FGS). Here, we show that the… read more here.
Keywords: contrast; fnir tag; fluorescence guided; somatostatin receptor ... See more keywords
AND-gate contrast agents for enhanced fluorescence-guided surgery.
Sign Up to like & getrecommendations! Published in 2020 at "Nature biomedical engineering"
DOI: 10.1038/s41551-020-00616-6
Abstract: Surgical resection of tumours requires precisely locating and defining the margins between lesions and normal tissue. However, this is made difficult by irregular margin borders. Although molecularly targeted optical contrast agents can be used to… read more here.
Keywords: contrast agents; surgery; gate contrast; contrast ... See more keywords
Fundamentals and developments in fluorescence-guided cancer surgery
Sign Up to like & getrecommendations! Published in 2021 at "Nature Reviews Clinical Oncology"
DOI: 10.1038/s41571-021-00548-3
Abstract: Fluorescence-guided surgery using tumour-targeted imaging agents has emerged over the past decade as a promising and effective method of intraoperative cancer detection. An impressive number of fluorescently labelled antibodies, peptides, particles and other molecules related… read more here.
Keywords: cancer; fluorescence guided; surgery; tumour targeted ... See more keywords
Indocyanine Green Fluorescence-Guided Surgery in Pediatric Hepatobiliary Procedures: A Feasibility Study for Improved Intraoperative Visualization
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Pediatric Surgery"
DOI: 10.1055/a-2509-4463
Abstract: Abstract Introduction Indocyanine green (ICG) fluorescence-guided surgery (FGS) is reported extensively in adult operations, but its safety and applications in pediatric populations remain to be comprehensively understood. The dose, administration protocols, and intraoperative imaging benefits… read more here.
Keywords: fluorescence; pediatric hepatobiliary; indocyanine green; fluorescence guided ... See more keywords