Aldehyde-derivatized indoles as fluorescent probes for hydration environments
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Physics"
DOI: 10.1016/j.chemphys.2019.110438
Abstract: Abstract Tryptophan derivatives have long been used as site-specific fluorescent probes. 4-cyanotryptophan emits in the visible region and is the smallest blue fluorescent amino acid probe. We performed UV–Vis, steady-state and time-resolved fluorescence spectroscopy on… read more here.
Keywords: fluorescent amino; aldehyde derivatized; fluorescent probes; probe ... See more keywords
A Scalable Synthesis of the Blue Fluorescent Amino Acid 4-Cyanotryptophan and the Fmoc Derivative: Utility Demonstrated with the Influenza M2 Peptide Tetramer.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.0c04055
Abstract: A scalable synthesis of the Fmoc-protected blue fluorescent amino acid, l-4-cyanotryptophan (W4CN), that exploits an enantioselective phase transfer-catalyzed alkylation is reported. The red-shifted emission of water-exposed W4CN residues was leveraged to investigate the solvation state… read more here.
Keywords: amino acid; acid cyanotryptophan; blue fluorescent; fluorescent amino ... See more keywords
Fluorescent d-Amino Acids for Super-resolution Microscopy of the Bacterial Cell Wall.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00496
Abstract: Fluorescent d-amino acids (FDAAs) have previously been developed to enable in situ highlighting of locations of bacterial cell wall growth. Most bacterial cells lie at the edge of the diffraction limit of visible light; thus,… read more here.
Keywords: amino acids; cell wall; microscopy; bacterial cell ... See more keywords
Fluorescent amino acids as versatile building blocks for chemical biology
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Chemistry"
DOI: 10.1038/s41570-020-0186-z
Abstract: Fluorophores have transformed the way we study biological systems, enabling non-invasive studies in cells and intact organisms, which increase our understanding of complex processes at the molecular level. Fluorescent amino acids have become an essential… read more here.
Keywords: fluorescent amino; biology; amino acids; building blocks ... See more keywords
Melittin Tryptophan Substitution with a Fluorescent Amino Acid Reveals the Structural Basis of Selective Antitumor Effect and Subcellular Localization in Tumor Cells
Sign Up to like & getrecommendations! Published in 2022 at "Toxins"
DOI: 10.3390/toxins14070428
Abstract: Melittin is a membrane-active peptide with strong anticancer activity against various cancers. Despite decades of research, the role of the singular Trp in the anticancer activity and selectivity of melittin remains poorly understood. Here, we… read more here.
Keywords: substitution; fluorescent amino; activity; amino acid ... See more keywords