Development of a Highly Specific, Selective, and Sensitive Fluorescent Probe for Detection of Mycobacteria in Human Tissues
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202102640
Abstract: Tuberculosis (TB), including extrapulmonary TB, is responsible for more than one million deaths in a year worldwide. Existing methods of mycobacteria detection have poor sensitivity, selectivity, and specificity, especially in human tissues. Herein, the synthesis… read more here.
Keywords: probe detect; detect mycobacteria; detection; fluorescent probe ... See more keywords
Specific spleen-accumulated NIR-II fluorescent probe for imaging-guided splenic operation.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300434
Abstract: Spleen is a large immune organ in body. Splenic operations such as splenectomy and intrasplenic injection are of paramount importance for immunological research and splenic diseases. Fluorescence imaging can vastly simplify these operations, but a… read more here.
Keywords: spleen accumulated; specific spleen; fluorescent probe; guided splenic ... See more keywords
Simultaneous Monitoring of Tyrosinase and ATP in Thick Brain Tissues Using a Single Two‐Photon Fluorescent Probe
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202413220
Abstract: Cellular redox homeostasis and energy metabolism in the central nervous system are associated with neurodegenerative diseases. However, their real‐time and concurrent monitoring in thick tissues remains challenging. Herein, a single dual‐emission two‐photon fluorescent probe (named… read more here.
Keywords: brain; fluorescent probe; photon fluorescent; monitoring ... See more keywords
Fluorescent Probe DCVJ Shows High Sensitivity for Characterization of Amyloid β‐Peptide Early in the Lag Phase
Sign Up to like & getrecommendations! Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201700387
Abstract: The aggregation of intrinsically disordered and misfolded proteins in the form of oligomers and fibrils plays a crucial role in a number of neurological and neurodegenerative diseases. Currently, most probes and biophysical techniques that detect… read more here.
Keywords: fluorescent probe; shows high; dcvj shows; sensitivity ... See more keywords
Specific Detection of Extended‐Spectrum β‐Lactamase Activities with a Ratiometric Fluorescent Probe
Sign Up to like & getrecommendations! Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201700447
Abstract: The dissemination of antimicrobial resistance around the world is one of the biggest threats to global public health. The acquisition and expression of extended‐spectrum β‐lactamases (ESBLs) in pathogenic bacterial are mainly responsible for bacterial resistance… read more here.
Keywords: fluorescent probe; detection; probe; ratiometric fluorescent ... See more keywords
Lessons in Organic Fluorescent Probe Discovery
Sign Up to like & getrecommendations! Published in 2021 at "ChemBioChem"
DOI: 10.1002/cbic.202100171
Abstract: Fluorescent probes have gained profound use in biotechnology, drug discovery, medical diagnostics, molecular and cell biology. The development of methods for the translation of fluorophores into fluorescent probes continues to be a robust field for… read more here.
Keywords: discovery; probe discovery; fluorescent probe; lessons organic ... See more keywords
High‐Throughput Screening of Signal Peptide Library with Novel Fluorescent Probe
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202100523
Abstract: Nitrile hydratase (NHase) is an excellent biocatalyst for the synthesis of amide compounds and is composed of two heterologous subunits. However, the secretory expression of NHase has been difficult to achieve because of its complex… read more here.
Keywords: peptide library; fluorescent probe; throughput screening; high throughput ... See more keywords
Discovery of Fluorescent Naturally‐Occurring Inhibitor of SARS‐CoV‐2 Main Protease by AIE Fluorescent Probe
Sign Up to like & getrecommendations! Published in 2024 at "ChemMedChem"
DOI: 10.1002/cmdc.202400311
Abstract: Target‐based high‐throughput screening (HTS) is an efficient way to identify potent drugs. However, the accuracy of HTS could be affected by Pan‐Assay Interference Compounds (PAINS). One reason for the generation of PAINS is that the… read more here.
Keywords: fluorescent; main protease; fluorescent probe; aie ... See more keywords
Novel fluorescent probe based on benzotriazole selective detection Hg2+ in real samples
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the Chinese Chemical Society"
DOI: 10.1002/jccs.202400367
Abstract: A novel reaction probe O‐(2‐(4‐(1H‐benzo[d][1,2,3]triazol‐1‐yl)phenyl)‐4‐oxo‐4H‐chromen‐3‐yl) O‐phenyl carbonothioate (O‐PCBE) synthesized from benzotriazole and benzopyrone. The structure was confirmed by NMR, HRMS, and IR characterization. The probe O‐PCBE was non‐fluorescent until Hg2+ was added, which markedly enhanced… read more here.
Keywords: detection; novel fluorescent; fluorescent probe; hg2 ... See more keywords
ESIPT mechanism of the HPQRB fluorescent probe and its ratiometric detection of SO2
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the Chinese Chemical Society"
DOI: 10.1002/jccs.70074
Abstract: A large amount of SO2 produced by large ships during fuel burning is a serious threat to people's health. It is urgently required to develop a method of detection with rapid response time and low… read more here.
Keywords: detection; hpqrb hso3; fluorescent probe; hpqrb ... See more keywords
Hypoxia Activated Fluorescent Probe Based on Self-immolative Block Copolymer.
Sign Up to like & getrecommendations! Published in 2022 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202100417
Abstract: This work reported a hypoxia activated fluorescent probe for tumor imaging by using self-immolative block copolymer with azobenzene linkage. The water-soluble polymer composed of self-immolative building blocks showed no obvious fluorescence. Under the hypoxic microenvironment… read more here.
Keywords: activated fluorescent; block copolymer; immolative block; fluorescent probe ... See more keywords