Effect of hesperidin on fluoride‐induced neurobehavioral and biochemical changes in rats
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22575
Abstract: Fluoride is the second largest contaminant of drinking water. Fluoride toxicity is a major concern in the endemic areas where a high amount of fluoride is present in ground water. Oxidative stress has been proposed… read more here.
Keywords: fluoride induced; biochemical changes; effect hesperidin; hesperidin ... See more keywords
Inhibition of autophagy reduces the rate of fluoride‐induced LS8 apoptosis via regulating ATG5 and ATG7
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23280
Abstract: Excessive fluoride affects ameloblast differentiation and tooth development. The fate of fluorinated ameloblasts is determined by multiple signaling pathways in response to a range of stimuli. Both autophagy and apoptosis are involved in the regulation… read more here.
Keywords: inhibition autophagy; atg5 atg7; fluoride induced; apoptosis ... See more keywords
miR‐486‐3p regulates CyclinD1 and promotes fluoride‐induced osteoblast proliferation and activation
Sign Up to like & getrecommendations! Published in 2021 at "Environmental Toxicology"
DOI: 10.1002/tox.23302
Abstract: Fluoride is a persistent environmental pollutant, and its excessive intake contributes to skeletal and dental fluorosis. The mechanisms underlying fluoride‐induced abnormal osteoblast proliferation and activation, which are related to skeletal fluorosis, have not yet been… read more here.
Keywords: fluoride induced; proliferation activation; mir 486; osteoblast proliferation ... See more keywords
Endoplasmic reticulum chaperone GRP78 participates in fluoride-induced autophagy in LS8 cells by regulating the IRE1-TRAF2-JNK pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental toxicology"
DOI: 10.1002/tox.23805
Abstract: Fluoride induces endoplasmic reticulum (ER) stress in ameloblasts, which is responsible for enamel mineralization disorder. Fluoride induces autophagy in ameloblasts, but the molecular mechanisms through which ameloblasts respond to fluoride-induced cellular stress and autophagy remain… read more here.
Keywords: chaperone grp78; stress; ls8 cells; fluoride induced ... See more keywords
Fluoride-Induced Expression of Neuroinflammatory Markers and Neurophysiological Regulation in the Brain of Wistar Rat Model.
Sign Up to like & getrecommendations! Published in 2020 at "Biological trace element research"
DOI: 10.1007/s12011-020-02362-x
Abstract: Excess fluoride intake has been linked with various pathological conditions. The objective of the present study was to understand the role of fluoride in neurotoxic, neuroinflammatory, and neurodegenerative changes in the brain tissue of Wistar… read more here.
Keywords: fluoride induced; neuroinflammatory markers; expression; fluoride ... See more keywords
Antioxidant Phytochemicals for the Prevention of Fluoride-Induced Oxidative Stress and Apoptosis: a Review.
Sign Up to like & getrecommendations! Published in 2021 at "Biological trace element research"
DOI: 10.1007/s12011-021-02729-8
Abstract: Fluorosis is a major public health problem globally. The non-availability of specific treatment and the irreversible nature of dental and skeletal lesions poses a challenge in the management of fluorosis. Oxidative stress is known to… read more here.
Keywords: fluoride induced; induced oxidative; stress; stress apoptosis ... See more keywords
Rescuing fluoride-induced damages in liver with gamma aminobutyric acid.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.07.015
Abstract: Fluorine poisoning affects human health all over the world and an urgent task is to develop alleviative medicine to recover or ameliorate the damages to the body. Here we studied the effects of gamma-aminobutyric acid… read more here.
Keywords: fluoride induced; gamma aminobutyric; rescuing fluoride; induced damages ... See more keywords
Neuroprotective influence of taurine on fluoride-induced biochemical and behavioral deficits in rats.
Sign Up to like & getrecommendations! Published in 2017 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2016.11.011
Abstract: Epidemiological and experimental studies have demonstrated that excessive exposure to fluoride induced neurodevelopmental toxicity both in humans and animals. Taurine is a free intracellular β-amino acid with antioxidant and neuroprotective properties. The present study investigated… read more here.
Keywords: fluoride induced; biochemical behavioral; neuroprotective influence; fluoride ... See more keywords
PI3K/AKT signaling pathway involvement in fluoride-induced apoptosis in C2C12 cells.
Sign Up to like & getrecommendations! Published in 2018 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2018.02.057
Abstract: To investigate the mechanisms of fluoride-induced apoptosis, a fluoride-induced C2C12 skeletal muscle cell (C2C12 cell) model was established in this study, and the viability of the C2C12 cells was measured using an MTT assay. Cell morphological changes… read more here.
Keywords: fluoride induced; c2c12 cells; induced apoptosis;
ITRAQ-based proteomics reveals the potential mechanism of fluoride-induced myocardial contraction function damage.
Sign Up to like & getrecommendations! Published in 2020 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2020.110605
Abstract: Fluorosis is a worldwide public health problem, and its adverse effects on the heart have been confirmed by many studies. Abnormal myocardial contractions are often associated with impairment of cardiac function as a cause or… read more here.
Keywords: fluoride induced; mechanism; myocardial contraction; function ... See more keywords
Sodium fluoride induced skeletal muscle changes: Degradation of proteins and signaling mechanism.
Sign Up to like & getrecommendations! Published in 2019 at "Environmental pollution"
DOI: 10.1016/j.envpol.2018.10.034
Abstract: Fluoride is a well-known compound for its usefulness in healing dental caries. Similarly, fluoride is also known for its toxicity to various tissues in animals and humans. It causes skeletal fluorosis leading to osteoporosis of… read more here.
Keywords: sodium fluoride; skeletal muscle; fluoride induced; concentration ppm ... See more keywords