A catalytic fluoride-rebound mechanism for C(sp3)-CF3 bond formation
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DOI: 10.1126/science.aan1411
Abstract: Trifluoromethylation via broken C-F bonds Trifluoromethyl substituents are widely used in pharmaceutical research to tune the properties of drug candidates. Generally, they are introduced intact through the formation of carbon-carbon bonds. Levin et al. discovered… read more here.
Keywords: mechanism; bond; fluoride rebound; sp3 cf3 ... See more keywords