Broad‐Spectrum Antifungal Agents: Fluorinated Aryl‐ and Heteroaryl‐Substituted Hydrazones
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DOI: 10.1002/cmdc.202000626
Abstract: Fluorinated aryl‐ and heteroaryl‐substituted monohydrazones displayed excellent broad‐spectrum activity against various fungal strains, including a panel of clinically relevant Candida auris strains relative to a control antifungal agent, voriconazole (VRC). These monohydrazones displayed less hemolysis… read more here.
Keywords: spectrum antifungal; fluorinated aryl; heteroaryl substituted; aryl heteroaryl ... See more keywords
New insights into the titanium-mediated enantioselective oxidation of fluorinated aryl benzyl sulfides and aryl phenacyl sulfides
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DOI: 10.1016/j.tet.2019.03.016
Abstract: Abstract A fruitful switch from tert-butyl to cumene hydroperoxide was able to overcome a difficulty arose in the enantioselective oxidation of fluorinated aryl benzyl sulfide with hydroperoxides in the presence of a titanium/(S, S)-hydrobenzoin catalyst.… read more here.
Keywords: enantioselective oxidation; aryl benzyl; fluorinated aryl; oxidation fluorinated ... See more keywords