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Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112323
Abstract: Inhibition of tubulin polymerisation with small molecules has been clinically validated as a promising therapy for multiple solid tumours. Herein, a series of chiral azetidin-2-ones were asymmetrically synthesised and biologically evaluated for antitumour activities. Among…
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Keywords:
tubulin polymerisation;
azetidin one;
fluorinated azetidin;
chiral fluorinated ... See more keywords