Enantioselective acyl-trifluoromethylation of olefins by bulky thiazolium carbene catalysis
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DOI: 10.1038/s41467-025-58423-z
Abstract: Enantioenriched α-chiral β-fluorinated ketones are valuable structural motifs with application in several fields. The recently emerged concept of NHC-catalyzed radical acyl-trifluoromethylation of olefins offers a rapid route to construct racemic β-fluorinated ketones in a single… read more here.
Keywords: trifluoromethylation olefins; acyl trifluoromethylation; thiazolium; fluorinated ketones ... See more keywords