Selective Metalation and Functionalization of Fluorinated Nitriles Using 2,2,6,6-Tetramethylpiperidyl Bases.
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DOI: 10.1021/acs.orglett.1c02572
Abstract: We have accomplished regioselective deprotometalation of aromatic and heteroaromatic nitriles via (TMP)2Zn·2MgCl2·2LiCl and TMPMgCl·LiCl (TMP = 2,2,6,6-tetramethylpiperidyl) with the exploration of new and scarcely investigated metalation positions. Regioselectivity was rationalized by DFT calculations. The quenching… read more here.
Keywords: metalation; metalation functionalization; tetramethylpiperidyl; fluorinated nitriles ... See more keywords