Novel dabigatran derivatives with a fluorine atom at the C-2 position of the terminal benzene ring: Design, synthesis and anticoagulant activity evaluation.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2016.12.015
Abstract: This manuscript describes the preparation of dabigatran derivatives and their inhibitory potentials toward human thrombin. Among the tested compounds, 7c, 7k, 7m and 7o, with IC50 values of 1.54, 0.84, 1.18 and 1.42 nM, exhibited comparable… read more here.
Keywords: novel dabigatran; activity; dabigatran; fluorine atom ... See more keywords
Triple photochemical domino reaction of a tetrafluorostilbene terminating in double fluorine atom transfer
Sign Up to like & getrecommendations! Published in 2018 at "Communications Chemistry"
DOI: 10.1038/s42004-018-0099-7
Abstract: In domino reactions, the product formed in one step undergoes a subsequent transformation under identical reaction conditions. Owing to the spontaneous nature of these reactions, it is difficult to isolate the key intermediates, and these… read more here.
Keywords: atom transfer; double fluorine; domino; fluorine atom ... See more keywords
Aromatic fluorine atom-induced highly amine-sensitive trimethine cyanine dye showing colorimetric and ratiometric fluorescence change
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra04387d
Abstract: Herein, introducing multiple fluorine atoms into aromatic rings of trimethine cyanine dyes is proposed as a powerful method for dramatically increasing sensitivity to amines. The highly sensitive ratiometric fluorescence properties previously available only by intramolecular… read more here.
Keywords: atom induced; fluorine atom; ratiometric fluorescence; trimethine cyanine ... See more keywords
Recent Innovations of Organo-Fluorine synthesis and pharmacokinetics
Sign Up to like & getrecommendations! Published in 2021 at "Current Organic Chemistry"
DOI: 10.2174/1385272825666210531111123
Abstract: The fluorinated compounds have significance in medicinal chemistry and pharmaceuticals research. The introduction of fluorine atom in the heterocyclic compounds increases biological activity, develops favourable physiochemical interaction. Combination of the heterocycles and fluorine substituent having… read more here.
Keywords: research; chemistry; drug; fluorine atom ... See more keywords