Unprotected peptide macrocyclization and stapling via a fluorine-thiol displacement reaction
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DOI: 10.1038/s41467-022-27995-5
Abstract: We report the discovery of a facile peptide macrocyclization and stapling strategy based on a fluorine thiol displacement reaction (FTDR), which renders a class of peptide analogues with enhanced stability, affinity, cellular uptake, and inhibition… read more here.
Keywords: displacement reaction; peptide macrocyclization; fluorine thiol; macrocyclization stapling ... See more keywords