Synthesis and Cytotoxic Evaluation of Fluoro and Trifluoromethyl Substituents Containing Novel Naphthoquinone-Fused Podophyllotoxins
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DOI: 10.1177/1934578x221133196
Abstract: A series of novel naphthoquinone-fused podophyllotoxins containing fluoro and trifluoromethyl substituents were synthesized in a medium with good yields using two different synthetic approaches: microwave-assisted four-component reactions of 2-hydroxy-1,4-naphthoquinone, tetronic acid, fluorinated arylaldehydes, and ammonium… read more here.
Keywords: naphthoquinone fused; novel naphthoquinone; fluoro trifluoromethyl; trifluoromethyl substituents ... See more keywords
Design and Synthesis of New α-hydroxy β-fluoro/β-trifluoromethyl and Unsaturated Phosphonates from Carbohydrate-Derived Building Blocks via Pudovik and Horner–Wadsworth–Emmons Reactions
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DOI: 10.3390/molecules27175404
Abstract: Herein, we present the application of fluorinated carbohydrate-derived building blocks for α-hydroxy β-fluoro/β-trifluoromethyl and unsaturated phosphonates synthesis. Pudovik and Horner–Wadsworth–Emmons reactions were applied to achieve this goal. The proposed pathway of the key reactions is… read more here.
Keywords: hydroxy fluoro; derived building; trifluoromethyl unsaturated; fluoro trifluoromethyl ... See more keywords
Polarity effects in 4-fluoro- and 4-(trifluoromethyl)prolines
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DOI: 10.3762/bjoc.16.151
Abstract: Fluorine-containing analogues of proline are valuable tools in engineering and NMR spectroscopic studies of peptides and proteins. Their use relies on the fundamental understanding of the interplay between the substituents and the main chain groups… read more here.
Keywords: effects fluoro; polarity effects; polarity; fluoro trifluoromethyl ... See more keywords