Unraveling the Nature of the Catalytic Power of Fluoroacetate Dehalogenase
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DOI: 10.1002/cctc.201701517
Abstract: Fluoroacetate dehalogenase is able to cleavage a carbon–fluoride bond, the strongest carbon–halogen bond in nature, in a process initiated by a SN2 reaction. The role of the enzyme machinery and particularly of the halogen pocket… read more here.
Keywords: fluoroacetate dehalogenase; sn2 reaction; unraveling nature; reaction ... See more keywords
Semirational Design of Fluoroacetate Dehalogenase RPA1163 for Kinetic Resolution of α-Fluorocarboxylic Acids on a Gram Scale
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DOI: 10.1021/acscatal.9b04804
Abstract: Here the synthetic utility of fluoroacetate dehalogenase RPA1163 is explored for the production of enantiomerically pure (R)-α-fluorocarboxylic acids and (R)-α-hydroxylcarboxylic acids via kinetic ... read more here.
Keywords: fluorocarboxylic acids; dehalogenase rpa1163; fluoroacetate dehalogenase;