In Vitro Characterization of the Colibactin-Activating Peptidase ClbP Enables Design of a Fluorogenic Activity Probe.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical biology"
DOI: 10.1021/acschembio.9b00540
Abstract: The gut bacterial genotoxin colibactin is linked to the development of colorectal cancer. In the final stages of colibactin’s biosynthesis, an inactive precursor (precolibactin) undergoes proteolytic cleavage by ClbP, an unusual inner-membrane-bound periplasmic peptidase, to… read more here.
Keywords: activity probe; fluorogenic activity; colibactin; vitro ... See more keywords