Fluorogenic Probes for Functional Imaging of Endoplasmic Reticulum‐Resident Proteins: from Molecular Engineering to Biomedical Applications
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202416057
Abstract: Endoplasmic reticulum‐resident proteins (ERPs) are crucial for maintaining cellular homeostasis and are tightly associated with the onset and progression of various diseases. The emergence of fluorogenic probes responsive to ERPs has enabled scientists to in… read more here.
Keywords: resident proteins; biomedical applications; fluorogenic probes; engineering ... See more keywords
Modular and Fast Assembly of Self-Immobilizing Fluorogenic Probes for β-Galactosidase Detection.
Sign Up to like & getrecommendations! Published in 2024 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.4c02307
Abstract: β-Galactosidase (β-gal) has emerged as a pivotal biomarker in primary ovarian cancer. Despite the existence of numerous fluorescent probes for β-gal activity detection, quinone methide-based immobilizing probes were shown to avoid rapid diffusion of the… read more here.
Keywords: detection; self immobilizing; fluorogenic probes; immobilizing fluorogenic ... See more keywords
Discovery of GPR84 Fluorogenic Probes Based on a Novel Antagonist for GPR84 Bioimaging.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.4c00359
Abstract: GPR84 is a promising therapeutic target and biomarker for a range of diseases. In this study, we reported the discovery of BINOL phosphate (BINOP) derivatives as GPR84 antagonists. By investigating the structure-activity relationship, we identified… read more here.
Keywords: fluorogenic probes; gpr84; discovery gpr84; gpr84 fluorogenic ... See more keywords
Fluorogenic Probes for Real-Time Tracking of Bacterial Cell Wall Dynamics with Nanoscopy.
Sign Up to like & getrecommendations! Published in 2025 at "ACS nano"
DOI: 10.1021/acsnano.5c01930
Abstract: The bacterial cell wall, an essential structure for maintaining cell morphology and protecting against environmental hazards, is predominantly composed of peptidoglycan (PG). This intricate macromolecule undergoes dynamic synthesis and remodeling throughout the cell cycle. Despite… read more here.
Keywords: real time; fluorogenic probes; cell wall; cell ... See more keywords
Rational Design of Esterase-Insensitive Fluorogenic Probes for In Vivo Imaging.
Sign Up to like & getrecommendations! Published in 2023 at "ACS sensors"
DOI: 10.1021/acssensors.3c00264
Abstract: Small-molecule fluorogenic probes are indispensable tools for performing research in biomedical fields and chemical biology. Although numerous cleavable fluorogenic probes have been developed to investigate various bioanalytes, few of them meet the baseline requirements for… read more here.
Keywords: esterase insensitive; fluorogenic probes; design esterase; insensitive fluorogenic ... See more keywords
Bioorthogonal Reaction of β-Chloroacroleins with meta-Aminothiophenol to Develop Near-Infrared Fluorogenic Probes for Simultaneous Two-color Imaging.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.4c16074
Abstract: Highly fluorogenic probe based bioorthogonal chemistry has become a promising tool in biomedical applications. However, the majority of fluorogenic probes are designed by introducing a bioorthogonal partner as a fluorescence quencher into classical fluorophores, and… read more here.
Keywords: fluorogenic probes; meta aminothiophenol; bioorthogonal reaction; two color ... See more keywords
Design of Antigen-Targeting Fluorogenic Probes Utilizing Intramolecular Addition Reaction of Protein-Dye Hybrids.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.5c04193
Abstract: Fluorogenic probes for antigens are useful for various purposes, including medical diagnostics and imaging, but achieving a rapid, large fluorescence increase is difficult. Here, we report a new class of fluorogenic probes for antigens based… read more here.
Keywords: reaction; antigen; fluorogenic probes; addition reaction ... See more keywords
Nitrile-aminothiol bioorthogonal near-infrared fluorogenic probes for ultrasensitive in vivo imaging
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-024-55452-y
Abstract: Bioorthogonal chemistry-mediated self-assembly holds great promise for dynamic molecular imaging in living organisms. However, existing approaches are limited to nanoaggregates with ‘always-on’ signals, suffering from high signal-to-background ratio (SBR) and compromised detection sensitivity. Herein we… read more here.
Keywords: detection; chemistry; fluorogenic probes; aminothiol bioorthogonal ... See more keywords
Recent advances in fluorogenic probes based on twisted intramolecular charge transfer (TICT) for live-cell imaging.
Sign Up to like & getrecommendations! Published in 2025 at "Chemical communications"
DOI: 10.1039/d5cc01802a
Abstract: Fluorescence imaging is a powerful technique for visualizing biological events in living samples, and new fluorescence-control mechanisms are still needed to extend the scope of biomolecule-targeting fluorogenic probes. Twisted intramolecular charge transfer (TICT) is a… read more here.
Keywords: charge transfer; fluorogenic probes; twisted intramolecular; intramolecular charge ... See more keywords