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   Articles with "fluorogenic rna" as a keyword



Fluorogenic RNA-Based Biosensor to Sense the Glycolytic Flux in Mammalian Cells.

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recommendations! Published in 2022 at "ACS chemical biology"

DOI: 10.1021/acschembio.2c00100

Abstract: The visualization of metabolic flux in real time requires sensor molecules that transduce variations of metabolite concentrations into an appropriate output signal. In this regard, fluorogenic RNA-based biosensors are promising molecular tools as they fluoresce… read more here.

Keywords: mammalian cells; fluorogenic rna; based biosensor; rna based ... See more keywords

Near-infrared fluorogenic RNA for in vivo imaging and sensing

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recommendations! Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-024-55093-1

Abstract: Fluorogenic RNA aptamers have various applications, including use as fluorescent tags for imaging RNA trafficking and as indicators of RNA-based sensors that exhibit fluorescence upon binding small-molecule fluorophores in living cells. Current fluorogenic RNA:fluorophore complexes… read more here.

Keywords: imaging sensing; fluorescence; fluorogenic rna; rna ... See more keywords

A fluorogenic RNA aptamer nanodevice for the low background imaging of mRNA in living cells.

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recommendations! Published in 2022 at "Chemical communications"

DOI: 10.1039/d1cc06582c

Abstract: A fluorogenic RNA aptamer nanodevice integrating an entropy-driven RNA amplifier with near-infrared (NIR) light control was developed, affording high contrast and sensitivity for imaging low-abundance mRNA in living cells. The design principle offers a new… read more here.

Keywords: aptamer nanodevice; rna aptamer; low background; living cells ... See more keywords

Transcriptionally amplified synthesis of fluorogenic RNA aptamers for label-free DNA glycosylase assay.

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recommendations! Published in 2022 at "Chemical communications"

DOI: 10.1039/d2cc03628b

Abstract: We demonstrate for the first time the utilization of fluorogenic RNA aptamers for label-free uracil-DNA glycosylase (UDG) assay. Through rationally engineering the transcription machine with dU substitution, this assay requires only a single probe to… read more here.

Keywords: label free; dna glycosylase; rna aptamers; aptamers label ... See more keywords

Structure-based insights into fluorogenic RNA aptamers

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recommendations! Published in 2024 at "Acta Biochimica et Biophysica Sinica"

DOI: 10.3724/abbs.2024142

Abstract: Fluorogenic RNA aptamers are in vitro-selected RNA molecules capable of binding to specific fluorophores, significantly increasing their intrinsic fluorescence. Over the past decade, the color palette of fluorescent RNA aptamers has greatly expanded. The emergence… read more here.

Keywords: rna aptamers; structure based; based insights; fluorogenic rna ... See more keywords