Structure‐Based Design of Fluorogenic Substrates Selective for Human Proteasome Subunits
Sign Up to like & getrecommendations! Published in 2020 at "Chembiochem"
DOI: 10.1002/cbic.202000375
Abstract: Proteasomes are established therapeutic targets for hematological cancers and promising targets for autoimmune diseases. In the past, we have designed and synthesized mechanism‐based proteasome inhibitors that are selective for the individual catalytic activities of human… read more here.
Keywords: design fluorogenic; proteasome; structure based; based design ... See more keywords
4-Bromo-1,8-naphthalimide derivatives as fluorogenic substrates for live cell imaging of glutathione S-transferase (GST) activity.
Sign Up to like & getrecommendations! Published in 2019 at "Talanta"
DOI: 10.1016/j.talanta.2019.06.059
Abstract: Fluorogenic substrates are used to visualize the activity of cancer-associated enzymes and to interpret biological events. Certain types of glutathione S-transferase (GST), such as Pi class GST (referred to as GSTP1), are more highly expressed… read more here.
Keywords: gst; activity; bromo naphthalimide; fluorogenic substrates ... See more keywords
Development of Fluorogenic Substrates of α-l-Fucosidase Useful for Inhibitor Screening and Gene-expression Profiling.
Sign Up to like & getrecommendations! Published in 2019 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.9b00259
Abstract: Inhibitors of human α-l-fucosidases, tissue α-l-fucosidase (tFuc), and plasma α-l-fucosidase reportedly play roles in multiple diseases, suggesting their therapeutic potential for gastric disease associated with Helicobacter pylori and fucosidosis. Terminal fucose linkages on glycoproteins and… read more here.
Keywords: gene expression; development; inhibitor screening; fluorogenic substrates ... See more keywords
Development of fluorogenic substrates for colorectal tumor-related neuropeptidases for activity-based diagnosis
Sign Up to like & getrecommendations! Published in 2023 at "Chemical Science"
DOI: 10.1039/d2sc07029d
Abstract: The M3 metalloproteases, neurolysin and THOP1, are neuropeptidases that are expressed in various tissues and metabolize neuropeptides, such as neurotensin. The biological roles of these enzymes are not well characterized, partially because the chemical tools… read more here.
Keywords: fluorogenic substrates; diagnosis; development fluorogenic; activity ... See more keywords