Novel Fluoroindenoisoquinoline Non-Camptothecin Topoisomerase I Inhibitors
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DOI: 10.1158/1535-7163.mct-18-0028
Abstract: Contrary to other anticancer targets, topoisomerase I (TOP1) is targeted by only one chemical class of FDA-approved drugs: topotecan and irinotecan, the derivatives of the plant alkaloid, camptothecin. The indenoisoquinolines LMP400, LMP744, and LMP776 are… read more here.
Keywords: camptothecin; novel fluoroindenoisoquinoline; fluoroindenoisoquinoline non; non camptothecin ... See more keywords