Case series of patients treated with the oral fluoropyrimidine S-1 after capecitabine-induced coronary artery vasospasm.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of cancer"
DOI: 10.1016/j.ejca.2017.05.022
Abstract: Fluoropyrimidines are widely used in cancer therapy for various solid tumours. Cardiotoxicity is an infrequent but relevant fluoropyrimidine-related toxicity, with a reported incidence in larger studies between 1.2% and 5.9% [1,2]. Its symptoms can be… read more here.
Keywords: oral fluoropyrimidine; capecitabine; coronary artery; fluoropyrimidine ... See more keywords
The clinical relevance of multiple DPYD polymorphisms on patients candidate for fluoropyrimidine based-chemotherapy. An Italian case-control study
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DOI: 10.1038/s41416-019-0423-8
Abstract: BackgroundDeleterious polymorphisms in the gene encoding DPD (DPYD) may result in severe reduction of DPD enzymatic activity that causes life-threatening toxicities when the standard dose of fluorouracil is used. The best panel of single-nucleotide polymorphism… read more here.
Keywords: dpyd; candidate fluoropyrimidine; fluoropyrimidine; fluoropyrimidine based ... See more keywords
A Systematic Review of Clinical Validated and Potential miRNA Markers Related to the Efficacy of Fluoropyrimidine Drugs
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DOI: 10.1155/2022/1360954
Abstract: Colorectal cancer (CRC) is becoming increasingly prevalent worldwide. Fluoropyrimidine drugs are the primary chemotherapy regimens in routine clinical practice of CRC. However, the survival rate of patients on fluoropyrimidine-based chemotherapy varies significantly among individuals. Biomarkers… read more here.
Keywords: fluoropyrimidine; efficacy fluoropyrimidine; fluoropyrimidine drugs; drug ... See more keywords
Addition of platinum derivatives to neoadjuvant single-agent fluoropyrimidine chemoradiotherapy in patients with stage II/III rectal cancer: protocol for a systematic review and meta-analysis (PROSPERO CRD42017073064)
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DOI: 10.1186/s13643-018-0678-9
Abstract: BackgroundNeoadjuvant (chemo-)radiation has proven to improve local control compared to surgery alone, but this improvement did not translate into better overall or disease-specific survival. The addition of oxaliplatin to fluoropyrimidine-based neoadjuvant chemoradiotherapy holds the potential… read more here.
Keywords: single agent; systematic review; chemoradiotherapy; fluoropyrimidine ... See more keywords
Prospective cohort study of the impact of hospital-wide dihydropyrimidine dehydrogenase (DPYD) genotype testing for fluoropyrimidine-based chemotherapy on adverse events and hospital costs.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.3028
Abstract: 3028 Background: Fluoropyrimidines remain integral components of modern chemotherapy for solid tumors, and their toxicities can be reduced by pretreatment DPYD genotyping. Our main objective was to demonstrate the feasibility of implementing a hospital-wide pretreatment… read more here.
Keywords: dpyd; hospital wide; pretreatment dpyd; fluoropyrimidine ... See more keywords
MTHFR c.665C>T guided fluoropyrimidine therapy in cancer: gender-dependent effect on dose requirements
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DOI: 10.1515/dmpt-2021-0219
Abstract: Abstract Objectives The fluoropyrimidine derivatives 5-Fluorouracil and Capecitabine are widely used for the treatment of solid tumors. Fluoropyrimidine metabolism involves a cascade of different enzymes, including MTHFR enzyme. MTHFR c.665C>T polymorphism, leading to decreased MTHFR… read more here.
Keywords: dose reduction; therapy; mthfr 665c; fluoropyrimidine ... See more keywords
Effectiveness of oral fluoropyrimidine monotherapy as adjuvant chemotherapy for high-risk stage II colon cancer
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DOI: 10.4174/astr.2022.102.5.271
Abstract: Purpose The benefit of adjuvant chemotherapy for stage II colon cancer has not been clearly demonstrated even in cases with high-risk factors. This study aimed to compare the effectiveness of oral fluoropyrimidine monotherapy as adjuvant… read more here.
Keywords: stage colon; fluoropyrimidine; high risk; colon cancer ... See more keywords