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Published in 2017 at "European journal of cancer"
DOI: 10.1016/j.ejca.2017.05.022
Abstract: Fluoropyrimidines are widely used in cancer therapy for various solid tumours. Cardiotoxicity is an infrequent but relevant fluoropyrimidine-related toxicity, with a reported incidence in larger studies between 1.2% and 5.9% [1,2]. Its symptoms can be…
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Keywords:
oral fluoropyrimidine;
capecitabine;
coronary artery;
fluoropyrimidine ... See more keywords
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Published in 2019 at "British Journal of Cancer"
DOI: 10.1038/s41416-019-0423-8
Abstract: BackgroundDeleterious polymorphisms in the gene encoding DPD (DPYD) may result in severe reduction of DPD enzymatic activity that causes life-threatening toxicities when the standard dose of fluorouracil is used. The best panel of single-nucleotide polymorphism…
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Keywords:
dpyd;
candidate fluoropyrimidine;
fluoropyrimidine;
fluoropyrimidine based ... See more keywords
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Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/1360954
Abstract: Colorectal cancer (CRC) is becoming increasingly prevalent worldwide. Fluoropyrimidine drugs are the primary chemotherapy regimens in routine clinical practice of CRC. However, the survival rate of patients on fluoropyrimidine-based chemotherapy varies significantly among individuals. Biomarkers…
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Keywords:
fluoropyrimidine;
efficacy fluoropyrimidine;
fluoropyrimidine drugs;
drug ... See more keywords
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Published in 2018 at "Systematic Reviews"
DOI: 10.1186/s13643-018-0678-9
Abstract: BackgroundNeoadjuvant (chemo-)radiation has proven to improve local control compared to surgery alone, but this improvement did not translate into better overall or disease-specific survival. The addition of oxaliplatin to fluoropyrimidine-based neoadjuvant chemoradiotherapy holds the potential…
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Keywords:
single agent;
systematic review;
chemoradiotherapy;
fluoropyrimidine ... See more keywords
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Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.3028
Abstract: 3028 Background: Fluoropyrimidines remain integral components of modern chemotherapy for solid tumors, and their toxicities can be reduced by pretreatment DPYD genotyping. Our main objective was to demonstrate the feasibility of implementing a hospital-wide pretreatment…
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Keywords:
dpyd;
hospital wide;
pretreatment dpyd;
fluoropyrimidine ... See more keywords
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Published in 2022 at "Drug Metabolism and Personalized Therapy"
DOI: 10.1515/dmpt-2021-0219
Abstract: Abstract Objectives The fluoropyrimidine derivatives 5-Fluorouracil and Capecitabine are widely used for the treatment of solid tumors. Fluoropyrimidine metabolism involves a cascade of different enzymes, including MTHFR enzyme. MTHFR c.665C>T polymorphism, leading to decreased MTHFR…
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Keywords:
dose reduction;
therapy;
mthfr 665c;
fluoropyrimidine ... See more keywords
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Published in 2022 at "Annals of Surgical Treatment and Research"
DOI: 10.4174/astr.2022.102.5.271
Abstract: Purpose The benefit of adjuvant chemotherapy for stage II colon cancer has not been clearly demonstrated even in cases with high-risk factors. This study aimed to compare the effectiveness of oral fluoropyrimidine monotherapy as adjuvant…
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Keywords:
stage colon;
fluoropyrimidine;
high risk;
colon cancer ... See more keywords