The clinical relevance of multiple DPYD polymorphisms on patients candidate for fluoropyrimidine based-chemotherapy. An Italian case-control study
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DOI: 10.1038/s41416-019-0423-8
Abstract: BackgroundDeleterious polymorphisms in the gene encoding DPD (DPYD) may result in severe reduction of DPD enzymatic activity that causes life-threatening toxicities when the standard dose of fluorouracil is used. The best panel of single-nucleotide polymorphism… read more here.
Keywords: dpyd; candidate fluoropyrimidine; fluoropyrimidine; fluoropyrimidine based ... See more keywords
Relevance of MTHFR polymorphisms with response to fluoropyrimidine-based chemotherapy in oesophagogastric cancer: a meta-analysis
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DOI: 10.1136/bmjopen-2017-020767
Abstract: Objective To evaluate the association between methylenetetrahydrofolate reductase (MTHFR) polymorphisms and the response to fluoropyrimidine-based chemotherapy in oesophagogastric cancer. Design Meta-analysis. Methods We searched PubMed, Embase and Web of Science databases from inception up to… read more here.
Keywords: response fluoropyrimidine; analysis; fluoropyrimidine based; based chemotherapy ... See more keywords
Exome array analysis of adverse reactions to fluoropyrimidine-based therapy for gastrointestinal cancer
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DOI: 10.1371/journal.pone.0188911
Abstract: Fluoropyrimidines, including 5-fluororacil (5FU) and its pro-drug Capecitabine, are the common treatment for colorectal, breast, neck and head cancers—either as monotherapy or in combination therapy. Adverse reactions (ADRs) to the treatment are common and often… read more here.
Keywords: array; array analysis; exome array; adverse reactions ... See more keywords