Synthesis, evaluation, and CoMFA study of fluoroquinophenoxazine derivatives as bacterial topoisomerase IA inhibitors.
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DOI: 10.1016/j.ejmech.2016.09.053
Abstract: New antibacterial agents with novel target and mechanism of action are urgently needed to combat problematic bacterial infections and mounting antibiotic resistances. Topoisomerase IA represents an attractive and underexplored antibacterial target, as such, there is… read more here.
Keywords: topoisomerase inhibitors; comfa; study; fluoroquinophenoxazine derivatives ... See more keywords