Articles with "fluorosulfate warhead" as a keyword



Photo by kellysikkema from unsplash

Covalent Inhibition of Wild-Type HIV-1 Reverse Transcriptase Using a Fluorosulfate Warhead.

Sign Up to like & get
recommendations!
Published in 2021 at "ACS medicinal chemistry letters"

DOI: 10.1021/acsmedchemlett.0c00612

Abstract: Covalent inhibitors of wild-type HIV-1 reverse transcriptase (CRTIs) are reported. Three compounds derived from catechol diether non-nucleoside inhibitors (NNRTIs) with addition of a fluorosulfate warhead are demonstrated to covalently modify Tyr181 of HIV-RT. X-ray crystal… read more here.

Keywords: type hiv; fluorosulfate warhead; hiv; hiv reverse ... See more keywords