Downregulation of glucose‐6‐phosphatase expression contributes to fluoxetine‐induced hepatic steatosis
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DOI: 10.1002/jat.4109
Abstract: Fluoxetine is a first‐line selective serotonin reuptake inhibitor widely applied for the treatment of depression; however, it induces abnormal hepatic lipid metabolism. Considering decreased expression or function of glucose‐6‐phosphatase (G6Pase), a key enzyme in gluconeogenesis,… read more here.
Keywords: hepatic steatosis; fatty acid; fluoxetine induced; expression ... See more keywords
Baicalin provides protection against fluoxetine-induced hepatotoxicity by modulation of oxidative stress and inflammation
Sign Up to like & getrecommendations! Published in 2022 at "World Journal of Hepatology"
DOI: 10.4254/wjh.v14.i4.729
Abstract: BACKGROUND Fluoxetine is one of the most widely prescribed anti-depressant drugs belonging to the category of selective serotonin reuptake inhibitors. Long-term fluoxetine treatment results in hepatotoxicity. Baicalin, a natural compound obtained from the Chinese herb… read more here.
Keywords: baicalin; inflammation; fluoxetine induced; oxidative stress ... See more keywords