LAUSR

Fluspirilene Analogs Activate the 20S Proteasome and Overcome Proteasome Impairment by Intrinsically Disordered Protein Oligomers.

Sign Up to like & get
recommendations!
0 Published in 2021 at "ACS chemical neuroscience"

DOI: 10.1021/acschemneuro.1c00099

Abstract: Oligomerization of aggregation-prone intrinsically disordered proteins (IDPs), such as α-synuclein, amyloid β, and tau, has been shown to be associated with the pathogenesis of several neurodegenerative diseases, including Parkinson's and Alzheimer's disease. The proteasome is… read more here.

Keywords: accumulation; proteasome; fluspirilene analogs; neurodegenerative diseases ... See more keywords