Potential targets of severe acute respiratory syndrome coronavirus 2 of clinical drug fluvoxamine: Docking and molecular dynamics studies to elucidate viral action
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3766
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has continued evolving for survival and adaptation by mutating itself into different variants of concern, including omicron. Several studies and clinical trials found fluvoxamine, an Food and Drug… read more here.
Keywords: fluvoxamine; severe acute; coronavirus; action ... See more keywords
Evaluation of the Effect of Fluvoxamine in Patients With Schizophrenia Under Risperidone Treatment: A Clinical Trial
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Psychopharmacology"
DOI: 10.1097/jcp.0000000000000850
Abstract: Purpose/Background The effectiveness of selective-serotonin reuptake inhibitors in the improvement of schizophrenia is a controversial issue. The aim of this study was to evaluate the effect of fluvoxamine on the symptoms of schizophrenia including positive… read more here.
Keywords: fluvoxamine; group; effect fluvoxamine; risperidone ... See more keywords
Safety and efficacy of fluvoxamine in COVID-19 ICU patients: an open label, prospective cohort trial with matched controls.
Sign Up to like & getrecommendations! Published in 2021 at "British journal of clinical pharmacology"
DOI: 10.1111/bcp.15126
Abstract: BACKGROUND Fluvoxamine, an SSRI and sigma-1 receptor agonist, has so far shown promise in the prevention of COVID-19 progression as an early treatment option in 3 conducted trials. The aim of this study was to… read more here.
Keywords: fluvoxamine; fluvoxamine covid; safety efficacy; efficacy fluvoxamine ... See more keywords
Influence of fluvoxamine on plasma interleukin-6 or clinical improvement in patients with major depressive disorder
Sign Up to like & getrecommendations! Published in 2017 at "Neuropsychiatric Disease and Treatment"
DOI: 10.2147/ndt.s123121
Abstract: Objectives The etiology of depression remains unknown. There is, however, a growing body of evidence that cytokines are involved in the pathophysiology of depression. The aim of this study is to investigate the effects of… read more here.
Keywords: fluvoxamine; depressive disorder; plasma interleukin; fluvoxamine plasma ... See more keywords
Effects of CYP2D6 genetic polymorphisms on the efficacy and safety of fluvoxamine in patients with depressive disorder and comorbid alcohol use disorder
Sign Up to like & getrecommendations! Published in 2018 at "Pharmacogenomics and Personalized Medicine"
DOI: 10.2147/pgpm.s160763
Abstract: Background Fluvoxamine therapy is used for treatment of patients with depressive disorder, but it is often ineffective, and some patients suffer from dose-dependent undesirable side effects such as vertigo, headache, indigestion, xerostomia, increased anxiety, etc.… read more here.
Keywords: patients depressive; fluvoxamine; depressive disorder; efficacy safety ... See more keywords
Impact of fluvoxamine on outpatient treatment of COVID-19 in Honduras in a prospective observational real-world study
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1054644
Abstract: Background: The COVID-19 pandemic has impacted millions of lives globally. While COVID-19 did not discriminate against developed or developing nations, it has been a significant challenge for third world countries like Honduras to have widespread… read more here.
Keywords: outpatient; relative risk; covid; fluvoxamine ... See more keywords
CYP2D6 gene polymorphism and apatinib affect the metabolic profile of fluvoxamine
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.985159
Abstract: This study aimed 1) to investigate the influence of CYP2D6 variants on the catalyzing of fluvoxamine, and 2) to study the interaction between fluvoxamine and apatinib. An enzymatic reaction system was setup and the kinetic… read more here.
Keywords: fluvoxamine; cyp2d6 gene; profile; cyp2d6 ... See more keywords
Trial Sequential Analysis and Updated Meta-Analysis of Fluvoxamine on Clinical Deterioration in Adult Patients with Symptomatic COVID-19 Infection
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Environmental Research and Public Health"
DOI: 10.3390/ijerph20054088
Abstract: Preliminary meta-analyses suggested that fluvoxamine was effective in treating COVID-19 infection. However, the reliability of this evidence has not yet been examined. MEDLINE, CENTRAL, EMBASE, PsycINFO, and ClinicalTrials.gov were searched to identify any randomized controlled… read more here.
Keywords: fluvoxamine; analysis; clinical deterioration; covid infection ... See more keywords
The Effects of Demographic Characteristics, Memory Deficits, and Executive Functioning Impairments in Failure to Respond to Fluvoxamine among Patients with Obsessive-Compulsive Disorder in Iran
Sign Up to like & getrecommendations! Published in 2022 at "Medical Journal of the Islamic Republic of Iran"
DOI: 10.47176/mjiri.36.13
Abstract: Background: Identifying treatment-response predictors could help improve treatment protocols as well as appropriately tailoring them to each subject, leading to a more desirable and accelerated recovery in patients. Thus, the present study aimed to investigate… read more here.
Keywords: executive functioning; memory deficits; treatment; fluvoxamine ... See more keywords
Role of 5-HT1A Receptor on Fluvoxamine induced Gastrointestinal Mucosa Protection and Healing in Animal with Stress-Induced Gastric Ulcer
Sign Up to like & getrecommendations! Published in 2023 at "Research Journal of Pharmacy and Technology"
DOI: 10.52711/0974-360x.2023.00121
Abstract: One factor that could contribute to the developing of gastric ulcer is stress. Fluvoxamine, an SSRI antidepressant showed protective effects to ulcers when administered before stress induction. In opposite, administration of fluvoxamine after stress induction… read more here.
Keywords: stress; stress induced; induced gastric; gastric ulcer ... See more keywords
In outpatients with mild to moderate COVID-19, low-dose fluvoxamine did not reduce time to sustained recovery
Sign Up to like & getrecommendations! Published in 2023 at "Annals of Internal Medicine"
DOI: 10.7326/j23-0025
Abstract: SOURCE CITATION McCarthy MW, Naggie S, Boulware DR, et al. Effect of fluvoxamine vs placebo on time to sustained recovery in outpatients with mild to moderate COVID-19: a randomized clinical trial. JAMA. 2023;329:296-305. 36633838. read more here.
Keywords: mild moderate; time sustained; moderate covid; outpatients mild ... See more keywords