NMDA receptors elicit flux-independent intracellular Ca2+ signals via metabotropic glutamate receptors and flux-dependent nitric oxide release in human brain microvascular endothelial cells.
Sign Up to like & getrecommendations! Published in 2021 at "Cell calcium"
DOI: 10.1016/j.ceca.2021.102454
Abstract: The excitatory neurotransmitter glutamate gates post-synaptic N-methyl-d-aspartate (NMDA) receptors (NMDARs) to mediate extracellular Ca2+ entry and stimulate neuronal nitric oxide (NO) synthase to release NO and trigger neurovascular coupling (NVC). Neuronal and glial NMDARs may… read more here.
Keywords: brain microvascular; flux independent; ca2; nmda receptors ... See more keywords
Ion flux-independent NMDA receptor signaling
Sign Up to like & getrecommendations! Published in 2022 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2022.109019
Abstract: NMDA receptors play vital roles in a broad array of essential brain functions, from synaptic transmission and plasticity to learning and memory. Historically, the fundamental roles of NMDARs were attributed to their specialized properties of… read more here.
Keywords: independent nmda; ion flux; flux independent; nmda receptor ... See more keywords
Flux-Independent NMDAR Signaling: Molecular Mediators, Cellular Functions, and Complexities
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DOI: 10.3390/ijms19123800
Abstract: The glutamate (Glu) N-methyl-d-aspartate (NMDA) receptor (NMDAR) plays a critical role in synaptic communication given mainly by its ionotropic function that permeates Ca2+. This in turn activates calmodulin that triggers CaMKII, MAPK, CREB, and PI3K… read more here.
Keywords: signaling molecular; independent nmdar; nmdar; flux independent ... See more keywords