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   Articles with "flux modes" as a keyword



Inference of dynamic macroscopic models of cell metabolism based on elementary flux modes analysis

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recommendations! Published in 2019 at "Biochemical Engineering Journal"

DOI: 10.1016/j.bej.2019.107325

Abstract: Abstract This study aims at providing a methodology based on both data- and knowledge-driven approaches to build dynamic macroscopic models of cell cultures. This methodology proceeds in three steps. A principal component analysis is first… read more here.

Keywords: elementary flux; methodology; models cell; flux modes ... See more keywords

Isotopic labelling reveals the efficient adaptation of wheat root TCA cycle flux modes to match carbon demand under ammonium nutrition

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recommendations! Published in 2019 at "Scientific Reports"

DOI: 10.1038/s41598-019-45393-8

Abstract: Proper carbon (C) supply is essential for nitrogen (N) assimilation especially when plants are grown under ammonium (NH4+) nutrition. However, how C and N metabolic fluxes adapt to achieve so remains uncertain. In this work,… read more here.

Keywords: flux modes; ammonium nutrition; nutrition; ammonium ... See more keywords
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Boosting the extraction of elementary flux modes in genome-scale metabolic networks using the linear programming approach

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recommendations! Published in 2020 at "Bioinformatics"

DOI: 10.1093/bioinformatics/btaa280

Abstract: Abstract Motivation Elementary flux modes (EFMs) are a key tool for analyzing genome-scale metabolic networks, and several methods have been proposed to compute them. Among them, those based on solving linear programming (LP) problems are… read more here.

Keywords: flux modes; genome scale; elementary flux; linear programming ... See more keywords

Algebraic differentiation for fast sensitivity analysis of optimal flux modes in metabolic models

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recommendations! Published in 2025 at "Bioinformatics"

DOI: 10.1093/bioinformatics/btaf287

Abstract: Abstract Motivation Sensitivity analysis is a useful tool to identify key parameters in metabolic models. It is typically only applied to the growth rate, disregarding the sensitivity of other solution variables to parameters. Further, sensitivity… read more here.

Keywords: metabolic models; sensitivity analysis; flux modes; sensitivity ... See more keywords