Fluconazole-loaded solid lipid nanoparticles topical gel for treatment of pityriasis versicolor: formulation and clinical study
Sign Up to like & getrecommendations! Published in 2018 at "Drug Delivery"
DOI: 10.1080/10717544.2017.1413444
Abstract: Abstract Solid lipid nanoparticles (SLNs) are very potential formulations for topical delivery of antifungal drugs. Hence, the purpose of this research was to formulate the well-known antifungal agent Fluconazole (FLZ)-loaded SLNs topical gel to improve… read more here.
Keywords: topical gel; treatment; solid lipid; lipid nanoparticles ... See more keywords
Antifungal susceptibility, genotyping, resistance mechanism, and clinical profile of Candida tropicalis blood isolates
Sign Up to like & getrecommendations! Published in 2019 at "Medical Mycology"
DOI: 10.1093/mmy/myz124
Abstract: Abstract Candida tropicalis is one of the major candidaemia agents, associated with the highest mortality rates among Candida species, and developing resistance to azoles. Little is known about the molecular mechanisms of azole resistance, genotypic… read more here.
Keywords: tropicalis; resistance; tropicalis blood; antifungal susceptibility ... See more keywords
Squamosamide Derivative FLZ Diminishes Aberrant Mitochondrial Fission by Inhibiting Dynamin-Related Protein 1
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.588003
Abstract: Mitochondrial dysfunction is involved in the pathogenesis of Parkinson’s disease (PD). Mitochondrial morphology is dynamic and precisely regulated by mitochondrial fission and fusion machinery. Aberrant mitochondrial fragmentation, which can result in cell death, is controlled… read more here.
Keywords: fission; aberrant mitochondrial; mitochondrial fission; related protein ... See more keywords
In Silico and In Vitro Analysis of Sulforaphane Anti-Candida Activity
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DOI: 10.3390/antibiotics11121842
Abstract: Oropharyngeal candidiasis/candidosis is a common and recurrent opportunistic fungal infection. Fluconazole (FLZ), one of the most used and effective antifungal agents, has been associated with a rise of resistant Candida species in immunocompromised patients undergoing… read more here.
Keywords: flz; candida activity; sfn; anti candida ... See more keywords
Novasomes as Nano-Vesicular Carriers to Enhance Topical Delivery of Fluconazole: A New Approach to Treat Fungal Infections
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DOI: 10.3390/molecules27092936
Abstract: The occurrence of fungal infections has increased over the past two decades. It is observed that superficial fungal infections are treated by conventional dosage forms, which are incapable of treating deep infections due to the… read more here.
Keywords: formulation; topical delivery; flz; fungal infections ... See more keywords