Modulation of receptor binding to collagen by glycosylated 5‐hydroxylysine: Chemical biology approaches made feasible by Carpino's Fmoc group
Sign Up to like & getrecommendations! Published in 2020 at "Peptide Science"
DOI: 10.1002/pep2.24156
Abstract: The creation of the 9‐fluorenylmethoxycarbonyl (Fmoc) group by the Carpino laboratory facilitated the synthesis of peptides containing acid‐sensitive groups, such as O‐linked glycosides. To fully investigative collagen biochemistry, one needs to assemble peptides that possess… read more here.
Keywords: collagen; fmoc; biology; hyl ... See more keywords
Improved enantioselective gram scale synthesis route to N-Fmoc-protected monofluoroethylglycine
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Fluorine Chemistry"
DOI: 10.1016/j.jfluchem.2020.109453
Abstract: Abstract Fluorine, as a substituent in amino acids, has found its way into peptide and protein engineering. The basis for the use of this valuable tool is the synthetic accessibility of various fluorinated amino acids… read more here.
Keywords: gram scale; fmoc; enantioselective gram; monofluoroethylglycine ... See more keywords
Environmentally Sensible Organocatalytic Fmoc/t-Bu Solid-Phase Peptide Synthesis.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00266
Abstract: Despite numerous reports on catalytic amide bond formation (ABF), these methods have thus far had a minimal impact on the universal fluorenylmethoxycarbonyl (Fmoc)/t-Bu solid-phase peptide synthesis (SPPS) methodology. We now report a proof-of-principle Fmoc/t-Bu SPPS… read more here.
Keywords: fmoc; synthesis; peptide synthesis; fmoc solid ... See more keywords
Chondroitin Sulfate-Derived Paclitaxel Nanocrystal via π-π Stacking with Enhanced Stability and Tumor Targetability.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c15881
Abstract: Nanocrystals with high drug loading have become a viable strategy for solubilizing drugs with poor aqueous solubility. It remains challenging, however, to synthesize nanocrystals with sufficient stability and targeting potential. Here, we report a novel… read more here.
Keywords: ptx fmoc; fmoc; chondroitin sulfate; via stacking ... See more keywords
Engineering UiO-68-Typed Homochiral Metal-Organic Frameworks for the Enantiomeric Separation of Fmoc-AAs and Mechanism Study.
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.3c01735
Abstract: Homochiral metal-organic frameworks (HMOFs) have been widely investigated in the application of enantiomeric separation. Nonetheless, it remains a significant challenge to explore the effect of multiple weak interactions between HMOF adsorbents and chiral adsorbates on… read more here.
Keywords: homochiral metal; fmoc; enantiomeric separation; separation ... See more keywords
Stabilizing gelatin-based bioinks under physiological conditions by incorporation of ethylene-glycol-conjugated Fmoc-FF peptides.
Sign Up to like & getrecommendations! Published in 2022 at "Nanoscale"
DOI: 10.1039/d1nr08206j
Abstract: Over the last decade, three-dimensional (3D) printing technologies have attracted the interest of researchers due to the possibility of fabricating tissue- and organ-like structures with similarities to the organ of interest. One of the most… read more here.
Keywords: based bioinks; stabilizing gelatin; gelatin based; fmoc ... See more keywords
Antibacterial hydrogels of aromatic tripeptides.
Sign Up to like & getrecommendations! Published in 2022 at "Soft matter"
DOI: 10.1039/d2sm00606e
Abstract: Self-assembled peptide hydrogels have emerged as alternatives to the conventional approaches employed in controlled drug release, wound-healing, and drug delivery, and as anti-infective agents. However, peptide hydrogels possessing antibacterial properties are less explored. In this… read more here.
Keywords: fmoc ffh; fmoc; conh2; peptide hydrogels ... See more keywords
Unique phase behaviour and self-assembly of a lysine derivative, Fmoc-homoarginine, in water-DMSO mixtures.
Sign Up to like & getrecommendations! Published in 2022 at "Soft matter"
DOI: 10.1039/d2sm00951j
Abstract: Ternary solutions of an amino acid derivative, Fmoc-homoarginine (Fmoc-hArg), dimethylsulfoxide (DMSO), and water exhibit unique phase behaviour. Fmoc-hArg is dissolved in DMSO to provide a clear solution, but the solution becomes turbid after aging (turn-over… read more here.
Keywords: phase behaviour; fmoc; water; unique phase ... See more keywords
Synthesis, experimental and in silico studies of N-fluorenylmethoxycarbonyl-O-tert-butyl-N-methyltyrosine, coupled with CSD data: a survey of interactions in the crystal structures of Fmoc-amino acids.
Sign Up to like & getrecommendations! Published in 2020 at "Acta crystallographica. Section C, Structural chemistry"
DOI: 10.1107/s2053229620003009
Abstract: Recently, fluorenylmethoxycarbonyl (Fmoc) amino acids (e.g. Fmoc-tyrosine or Fmoc-phenylalanine) have attracted growing interest in biomedical research and industry, with special emphasis directed towards the design and development of novel effective hydrogelators, biomaterials or therapeutics. With… read more here.
Keywords: amino acids; fmoc; fmoc amino; crystal structures ... See more keywords
New Fmoc-Amino Acids/Peptides-Based Supramolecular Gels Obtained through Co-Assembly Process: Preparation and Characterization
Sign Up to like & getrecommendations! Published in 2022 at "Polymers"
DOI: 10.3390/polym14163354
Abstract: One of the methods of obtaining supramolecular gels consists of the possibility of self-assembly of low molecular weight gelators (LMWGs). However, LMWG-based gels are often difficult to handle, easy to destroy and have poor rheological… read more here.
Keywords: amino acids; fmoc; acids peptides; new fmoc ... See more keywords