Epitope-based sieve analysis of Plasmodium falciparum sequences from a FMP2.1/AS02A vaccine trial is consistent with differential vaccine efficacy against immunologically relevant AMA1 variants.
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DOI: 10.1016/j.vaccine.2020.06.035
Abstract: To prevent premature dismissal of promising vaccine programs, it is critical to determine if lack of efficacy in the field is due to allele specific-efficacy, rather than to the lack of immunogenicity of the candidate… read more here.
Keywords: ama1; trial; efficacy; fmp2 as02a ... See more keywords