Spontaneous seizures in adult Fmr1 knockout mice: FVB.129P2-Pde6b + Tyr c-ch Fmr1 tm1Cgr /J
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsy Research"
DOI: 10.1016/j.eplepsyres.2022.106891
Abstract: The prevalence of seizures in individuals with fragile X syndrome (FXS) is ~25%; however, there are no reports of spontaneous seizures in the Fmr1 knockout mouse model of FXS. Herein, we report that 48% of… read more here.
Keywords: adult fmr1; knockout mice; fmr1 knockout;
FPT, a 2-Aminotetralin, Is a Potent Serotonin 5-HT1A, 5-HT1B, and 5-HT1D Receptor Agonist That Modulates Cortical Electroencephalogram Activity in Adult Fmr1 Knockout Mice.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00574
Abstract: There are no approved medicines for fragile X syndrome (FXS), a monogenic, neurodevelopmental disorder. Electroencephalogram (EEG) studies show alterations in resting-state cortical EEG spectra, such as increased gamma-band power, in patients with FXS that are… read more here.
Keywords: fpt; power; fmr1 knockout; knockout mice ... See more keywords
Premature recruitment of oocyte pool and increased mTOR activity in Fmr1 knockout mice and reversal of phenotype with rapamycin
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-18598-y
Abstract: While mutations in the fragile X mental retardation-1 (FMR1) gene are associated with varying reproductive outcomes in females, the effects of a complete lack of FMR1 expression are not known. Here, we studied the ovarian… read more here.
Keywords: pool; mtor signaling; mtor; mice ... See more keywords
Adult Fmr1 knockout mice present with deficiencies in hippocampal interleukin-6 and tumor necrosis factor-&agr; expression
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DOI: 10.1097/wnr.0000000000000905
Abstract: Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by a single genetic mutation in the FMR1 gene. Mutations in the FMR1 gene are the largest monogenic cause of autism spectrum disorder (ASD), and thus… read more here.
Keywords: fmr1; expression; tumor necrosis; mice ... See more keywords
Multiple Early-Life Seizures Alters Neonatal Communicative Behavior in Fmr1 Knockout Mice
Sign Up to like & getrecommendations! Published in 2022 at "Developmental Neuroscience"
DOI: 10.1159/000524898
Abstract: Fragile X syndrome (FXS) is the leading monogenic cause of intellectual disability and a significant contributor to Autism Spectrum Disorder. Individuals with FXS are subject to developing numerous comorbidities, one of the most prevalent being… read more here.
Keywords: early life; life seizures; knockout mice; fmr1 knockout ... See more keywords