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Alterations in CA1 hippocampal synapses in a mouse model of fragile X syndrome

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1 Published in 2018 at "Glia"

DOI: 10.1002/glia.23284

Abstract: Fragile X Syndrome (FXS) is the major cause of inherited mental retardation and the leading genetic cause of Autism spectrum disorders. FXS is caused by mutations in the Fragile X Mental Retardation 1 (Fmr1) gene,… read more here.

Keywords: fmr1 mice; ca1 hippocampal; fragile syndrome; microscopy ... See more keywords

Adenosine A2A receptor inhibition reduces synaptic and cognitive hippocampal alterations in Fmr1 KO mice

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0 Published in 2021 at "Translational Psychiatry"

DOI: 10.1038/s41398-021-01238-5

Abstract: In fragile X syndrome (FXS) the lack of the fragile X mental retardation protein (FMRP) leads to exacerbated signaling through the metabotropic glutamate receptors 5 (mGlu5Rs). The adenosine A 2A receptors (A 2A Rs), modulators… read more here.

Keywords: fmr1 mice; inhibition reduces; receptor inhibition; adenosine a2a ... See more keywords

Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice

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1 Published in 2018 at "Molecular Brain"

DOI: 10.1186/s13041-018-0396-1

Abstract: Fragile X syndrome is caused by the loss of fragile X mental retardation protein (FMRP). Kainate receptor (KAR) is a subfamily of ionotropic glutamate receptors (iGluR) that acts mainly as a neuromodulator of synaptic transmission… read more here.

Keywords: fmr1 mice; cortex fmr1; insular cortex; mice ... See more keywords

Parallel learning and cognitive flexibility impairments between Fmr1 knockout mice and individuals with fragile X syndrome

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2 Published in 2023 at "Frontiers in Behavioral Neuroscience"

DOI: 10.3389/fnbeh.2022.1074682

Abstract: Introduction Fragile X Syndrome (FXS) is a monogenic condition that leads to intellectual disability along with behavioral and learning difficulties. Among behavioral and learning difficulties, cognitive flexibility impairments are among the most commonly reported in… read more here.

Keywords: cognitive flexibility; reversal learning; fmr1 mice;