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   Articles with "fmrp" as a keyword



Cellular distribution of the Fragile X mental retardation protein in the inner ear: a developmental and comparative study in the mouse, rat, gerbil, and chicken

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recommendations! Published in 2022 at "Journal of Comparative Neurology"

DOI: 10.1002/cne.25420

Abstract: The Fragile X mental retardation protein (FMRP) is an mRNA binding protein that is essential for neural circuit assembly and synaptic plasticity. Loss of functional FMRP leads to Fragile X syndrome (FXS), a neurodevelopmental disorder… read more here.

Keywords: fragile mental; inner ear; mental retardation; fmrp ... See more keywords

Characterization of Fragile X Mental Retardation Protein expression in human nociceptors and their axonal projections to the spinal dorsal horn

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recommendations! Published in 2023 at "Journal of Comparative Neurology"

DOI: 10.1002/cne.25463

Abstract: Fragile X Mental Retardation Protein (FMRP) regulates activity‐dependent RNA localization and local translation to modulate synaptic plasticity throughout the central nervous system. Mutations in the FMR1 gene that hinder or ablate FMRP function cause Fragile… read more here.

Keywords: fragile mental; retardation protein; mental retardation; fmrp ... See more keywords

Loss of fragile X mental retardation protein precedes Lewy pathology in Parkinson’s disease

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recommendations! Published in 2019 at "Acta Neuropathologica"

DOI: 10.1007/s00401-019-02099-5

Abstract: Parkinson’s disease (PD) is the most common neurodegenerative movement disorder and is characterized by the progressive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc) and the gradual appearance of α-synuclein (α-syn)-containing… read more here.

Keywords: protein; fragile mental; pathology; fmrp ... See more keywords

FMRP Interacts with C/D Box snoRNA in the Nucleus and Regulates Ribosomal RNA Methylation

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recommendations! Published in 2018 at "iScience"

DOI: 10.1016/j.isci.2018.11.007

Abstract: Summary FMRP is an RNA-binding protein that is known to localize in the cytoplasm and in the nucleus. Here, we have identified an interaction of FMRP with a specific set of C/D box snoRNAs in… read more here.

Keywords: fmrp interacts; methylation; nucleus; ribosomal rna ... See more keywords

FMRP promotes transcription-coupled homologous recombination via facilitating TET1-mediated m5C RNA modification demethylation

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2116251119

Abstract: Significance This study shows that Fragile X mental retardation protein (FMRP) promotes messenger RNA (mRNA)-dependent recombination via facilitating ten-eleven translocation protein 1 (TET1)-mediated mRNA methyl-5-cytosine (m5C) demethylation. Loss of FMRP leads to damage induced mRNA… read more here.

Keywords: tet1; recombination; demethylation; fmrp ... See more keywords

Upregulation of FMRP Is Involved in Neuropathic Pain by Regulating GluN2B Activation in Rat Spinal Cord

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recommendations! Published in 2025 at "Journal of Neurochemistry"

DOI: 10.1111/jnc.70022

Abstract: Fragile X mental retardation protein (FMRP) has been proposed to play a potential role in the pathogenesis of autonomy and nociceptive paresthesia. However, the involvement of spinal FMRP in neuropathic pain remains unexplored. Using a… read more here.

Keywords: fmrp; pain; glun2b; neuropathic pain ... See more keywords

Aberrant hyperexpression of the RNA binding protein FMRP in tumors mediates immune evasion

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recommendations! Published in 2022 at "Science"

DOI: 10.1126/science.abl7207

Abstract: Many human cancers manifest the capability to circumvent attack by the adaptive immune system. In this work, we identified a component of immune evasion that involves frequent up-regulation of fragile X mental retardation protein (FMRP)… read more here.

Keywords: cancer; fmrp; rna; tumor ... See more keywords

DJ-1-mediated repression of the RNA-binding protein FMRP is predicted to impact known Alzheimer's disease-related protein networks

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recommendations! Published in 2024 at "Journal of Alzheimer's Disease"

DOI: 10.1177/13872877241291175

Abstract: Background RNA-binding proteins (RBPs) modulate the synaptic proteome and are instrumental in maintaining synaptic homeostasis. Moreover, aberrant expression of an RBP in a disease state would have deleterious downstream effects on synaptic function. While many… read more here.

Keywords: alzheimer disease; disease; fmrp; disease related ... See more keywords

Oppositional Poly(A) Tail Length Regulation by FMRP and CPEB1.

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recommendations! Published in 2022 at "RNA"

DOI: 10.1261/rna.079050.121

Abstract: Poly(A) tail length is regulated in both the nucleus and cytoplasm. One factor that controls polyadenylation in the cytoplasm is CPEB1, an RNA binding protein that associates with specific mRNA 3'UTR sequences to tether enzymes… read more here.

Keywords: tail length; poly tail; poly; fmrp ... See more keywords

Combining affinity purification and mass spectrometry to define the network of the nuclear proteins interacting with the N-terminal region of FMRP

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recommendations! Published in 2022 at "Frontiers in Molecular Biosciences"

DOI: 10.3389/fmolb.2022.954087

Abstract: Fragile X-Syndrome (FXS) represents the most common inherited form of intellectual disability and the leading monogenic cause of Autism Spectrum Disorders. In most cases, this disease results from the absence of expression of the protein… read more here.

Keywords: mass spectrometry; fmrp; affinity purification; nuclear proteins ... See more keywords

Fragile X Mental Retardation Protein Regulates Activity-Dependent Membrane Trafficking and Trans-Synaptic Signaling Mediating Synaptic Remodeling

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recommendations! Published in 2018 at "Frontiers in Molecular Neuroscience"

DOI: 10.3389/fnmol.2017.00440

Abstract: Fragile X syndrome (FXS) is the leading monogenic cause of autism and intellectual disability. The disease arises through loss of fragile X mental retardation protein (FMRP), which normally exhibits peak expression levels in early-use critical… read more here.

Keywords: protein; membrane trafficking; synaptic remodeling; fmrp ... See more keywords