Gene-set analysis shows association between FMRP targets and autism spectrum disorder
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Human Genetics"
DOI: 10.1038/ejhg.2017.55
Abstract: Autism spectrum disorder (ASD) is a heterogeneous group of disorders characterized by problems with social interaction, communication, and repetitive and restricted behavior. Despite its high heritability and the substantial progress made in elucidating genetic associations,… read more here.
Keywords: gene set; fmrp targets; spectrum disorder; gene ... See more keywords
Genetic association of FMRP targets with psychiatric disorders
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Psychiatry"
DOI: 10.1038/s41380-020-00912-2
Abstract: Genes encoding the mRNA targets of fragile X mental retardation protein (FMRP) are enriched for genetic association with psychiatric disorders. However, many FMRP targets possess functions that are themselves genetically associated with psychiatric disorders, including… read more here.
Keywords: genetic association; fmrp targets; psychiatric disorders; disorder ... See more keywords
FMRP regulates mRNAs encoding distinct functions in the cell body and dendrites of CA1 pyramidal neurons
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DOI: 10.7554/elife.71892
Abstract: Neurons rely on translation of synaptic mRNAs in order to generate activity-dependent changes in plasticity. Here, we develop a strategy combining compartment-specific crosslinking immunoprecipitation (CLIP) and translating ribosome affinity purification (TRAP) in conditionally tagged mice… read more here.
Keywords: ca1 pyramidal; fmrp; fmrp targets; fmrp regulates ... See more keywords