Predictive value of soluble fms‐like tyrosine kinase‐1 against placental growth factor for preeclampsia in a Chinese pregnant women population
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.22861
Abstract: The purpose of the present study was to explore the predictive effects of soluble fms‐like tyrosine kinase‐1 (sFlt‐1) and placental growth factor (PlGF) for preeclampsia. read more here.
Keywords: fms like; like tyrosine; placental growth; growth factor ... See more keywords
Real-world data on the clinical use of angiogenic factors in pregnancies with placental dysfunction.
Sign Up to like & getrecommendations! Published in 2021 at "American journal of obstetrics and gynecology"
DOI: 10.1016/j.ajog.2020.10.028
Abstract: BACKGROUND In routine clinical practice, angiogenic factor measurement can facilitate prediction and diagnosis of preeclampsia and other manifestations of placental dysfunction (eg, intrauterine growth restriction). OBJECTIVE This real-world data analysis investigated the utility of soluble… read more here.
Keywords: like tyrosine; soluble fms; factor; growth ... See more keywords
Soluble FMS-Like Tyrosine Kinase-1 Is a Circulating Biomarker Associated With Calcific Aortic Stenosis.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2019.01.020
Abstract: Calcific aortic stenosis (CAS) is the end manifestation of calcific aortic valve disease (CAVD). There are no medical therapies to reverse or slow the progression of CAVD [(1)][1]. Circulating biomarkers may provide insights into CAVD… read more here.
Keywords: like tyrosine; aortic stenosis; soluble fms; calcific aortic ... See more keywords
Placental Growth Factor and Soluble, Fms-Like Tyrosine Kinase-1 in Preeclampsia: A Case-Cohort (PEARL) Study.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC"
DOI: 10.1016/j.jogc.2020.03.024
Abstract: OBJECTIVE Preeclampsia is associated with a higher maternal blood levels of soluble fms-like tyrosine kinase-1 (sFlt-1) and lower levels of placental growth factor (PlGF) that appear before clinical onset. We aimed to estimate the normal… read more here.
Keywords: like tyrosine; cohort; soluble fms; preeclampsia ... See more keywords
Small-molecule Fms-like Tyrosine Kinase 3 Inhibitors: An Attractive and Efficient Method for the Treatment of Acute Myeloid Leukemia.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c00696
Abstract: Fms-like tyrosine kinase 3 (FLT3) is an important member of the class III receptor tyrosine kinase (RTK) family, which is involved in the proliferation of hematopoietic cells and lymphocytes. In recent years, increasing evidence have… read more here.
Keywords: like tyrosine; kinase; myeloid leukemia; acute myeloid ... See more keywords
Discovery of N-(4-(6-Acetamidopyrimidin-4-yloxy)phenyl)-2-(2-(trifluoromethyl)phenyl)acetamide (CHMFL-FLT3-335) as a Potent FMS-like Tyrosine Kinase 3 Internal Tandem Duplication (FLT3-ITD) Mutant Selective Inhibitor for Acute Myeloid Leukemia.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b01594
Abstract: Most of the current FMS-like tyrosine kinase 3 (FLT3) inhibitors lack selectivity between FLT3 kinase and cKIT kinase as well as the FLT3 wt and internal tandem duplication (ITD) mutants. We report a new compound… read more here.
Keywords: kinase; flt3; phenyl; flt3 itd ... See more keywords
Rational design and synthesis of 2-(1H-indazol-6-yl)-1H-benzo[d]imidazole derivatives as inhibitors targeting FMS-like tyrosine kinase 3 (FLT3) and its mutants
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2021.2020772
Abstract: Abstract Fms-like tyrosine kinase 3 (FLT3) has been verified as a therapeutic target for acute myeloid leukaemia (AML). In this study, we report a series of 2-(1H-indazol-6-yl)-1H-benzo[d]imidazol-5-yl benzamide and phenyl urea derivatives as potent FLT3… read more here.
Keywords: flt3; kinase flt3; like tyrosine; flt3 mutants ... See more keywords
Upregulation and release of soluble fms‐like tyrosine kinase receptor 1 mediated by complement activation in human syncytiotrophoblast cells
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DOI: 10.1111/aji.13033
Abstract: Antiangiogenic molecule soluble fms‐like tyrosine kinase receptor 1 (sFLT1) released from trophoblast cells is associated with pregnancy‐specific hypertensive disorder pre‐eclampsia. Cause of elevated sFLT1 in pre‐eclampsia patients is not well understood. Despite evidence of excess… read more here.
Keywords: like tyrosine; soluble fms; activation; complement activation ... See more keywords
Single‐cell RNA sequencing distinguishes dendritic cell subsets in the rat, allowing advanced characterization of the effects of FMS‐like tyrosine kinase 3 ligand
Sign Up to like & getrecommendations! Published in 2022 at "Scandinavian Journal of Immunology"
DOI: 10.1111/sji.13159
Abstract: Tissue‐resident dendritic cells (DCs) are essential for immunological homeostasis and hold promise for a variety of therapeutic interventions. The rare nature of tissue‐resident DCs and their suboptimal description in the lab rat model has limited… read more here.
Keywords: cell; tissue resident; like tyrosine; tyrosine kinase ... See more keywords
The FMS-like tyrosine kinase-3 ligand/lung dendritic cell axis contributes to regulation of pulmonary fibrosis
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DOI: 10.1136/thoraxjnl-2018-212603
Abstract: Rationale Dendritic cells (DC) accumulate in the lungs of patients with idiopathic lung fibrosis, but their pathogenetic relevance is poorly defined. Objectives To assess the role of the FMS-like tyrosine kinase-3 ligand (Flt3L)-lung dendritic cell… read more here.
Keywords: fibrosis; like tyrosine; mice; lung fibrosis ... See more keywords
Activating Transcription Factor 3 Is Reduced in Preeclamptic Placentas and Negatively Regulates sFlt-1 (Soluble fms-Like Tyrosine Kinase 1), Soluble Endoglin, and Proinflammatory Cytokines in Placenta
Sign Up to like & getrecommendations! Published in 2017 at "Hypertension"
DOI: 10.1161/hypertensionaha.117.09548
Abstract: Preeclampsia is a major pregnancy complication associated with poor placental perfusion and placental hypoxia. Systemic and placental inflammation and elevated placental secretion of the antiangiogenic factors sFlt-1 (soluble fms-like tyrosine kinase 1) and sEng (soluble… read more here.
Keywords: preeclamptic placentas; atf3; soluble fms; factor ... See more keywords